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CALM3 — NFKB1

Text-mined interactions from Literome

Choi et al., Glia 2001 (Brain Injuries) : NF-kappaB activation by N-CAM and cytokines in astrocytes is regulated by multiple protein kinases and redox modulation ... These findings suggest that activation of NF-kappaB by N-CAM and cytokines in astrocytes involves multiple signals that differentially affect NF-kappaB nuclear translocation, DNA binding, and transactivation
Little et al., Proc Natl Acad Sci U S A 2001 : A short segment within the cytoplasmic domain of the neural cell adhesion molecule ( N-CAM ) is essential for N-CAM induced NF-kappa B activity in astrocytes ... Transfection of astrocytes with a construct encompassing the transmembrane region and the cytoplasmic domain of N-CAM ( designated Tm-Cyto, amino acids 685-839 in the full-length molecule ) inhibited this activation up to 40 %, and inhibited N-CAM induced translocation of NF-kappaB to the nucleus ... N-CAM also activated NF-kappaB in astrocytes from N-CAM knockout mice, presumably through binding to a heterophile ... Overall, these findings define a short segment of the N-CAM cytoplasmic domain that is critical for N-CAM induced activation of NF-kappaB and may be important in other N-CAM mediated signaling
Chen et al., Invest Ophthalmol Vis Sci 2005 : DHA ( 22 : 6n3 ) inhibited cytokine induced CAM expression through suppression of NF-kappaB nuclear translocation and upstream I-kappaBalpha phosphorylation and degradation
Waldow et al., Nitric Oxide 2006 : The TNFalpha induced expression of CAM was exclusively dependent on the transcription factor NFkappaB since the inhibitor of NFkappaB activation, BAY 11-7082, completely blocked the induction ... In summary, a short preincubation of HUVEC with SNAP/Cys results in a persistent suppression of NFkappaB dependent expression of CAM
Cirillo et al., J Vasc Res 2007 (Atherosclerosis) : Superoxide dimutase, Rho A ( Y-27639 ) and NF-kappaB inhibitors ( pyrrolidine dithiocarbamate ammonium, Bay 11-7082 ) suppressed nicotine effects on CAM expression
Yang et al., Molecular cancer 2008 (Lymphoma, Mantle-Cell) : Consistent with a proteasome inhibitor resistant pathway of activation described in mouse B-lymphoma cells ( WEHI231 ) and a breast carcinoma cell line ( MDA-MB-468 ), the bortezomib-resistant NF-kappaB activity in Rec-1 cells is inhibited by calcium chelators, calmodulin inhibitors, and perillyl alcohol, a monoterpene capable of blocking L-type calcium channels
Rajan et al., J Cell Biochem 2008 : Taken together, our results clearly demonstrate that NF-kappaB , but not p38, is critical for TNF-alpha induced CAM expression
Krushel et al., J Biol Chem 1999 : These results indicate that N-CAM homophilic binding at the cell membrane leads to increased NF-kappaB binding to DNA and transcriptional activation in both neurons and astrocytes