◀ Back to CCND2
CCND2 — PCNA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Lee et al., Eur J Immunol 2003
(MAP Kinase Signaling System) :
The enhanced
cyclin D2 and D3 expression
initiates up-regulation of
cyclin E expression and down-regulation of p27 ( kip1 )
Liu et al., J Neurosci 2006
:
Our present study shows that c-Myc was significantly induced and that it inhibited p21 and induced proteins such as
cyclin dependent kinases,
cyclin D , and cyclin E, which are involved in the cell cycle process, along with phosphorylation of the retinoblastoma protein and Cdc2 ( cell division cycle 2 )
Lavine et al., Mol Endocrinol 2008
:
Analysis of cyclin and cdk mRNA and protein abundance revealed that CCK overexpression
increased cyclin A, cyclin B,
cyclin E, cdk1, and cdk2 with no change in cyclin D1,
cyclin D2 , cyclin D3, cdk4, or cdk6 in mouse and human islets
Sweeney et al., Oncogene 1997
(Breast Neoplasms) :
Induced expression of
cyclin D2 resulted in increases in
cyclin E expression, pRB phosphorylation and the percentage of cells in S-phase, while constitutive expression resulted in a consistent trend toward reduced dependence on serum for continued proliferation