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SIK1 — STK11

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SIK1 → STK11 (directlyIncreases, SIK1 Activity) Lizcano et al., EMBO J 2004*
  Evidence: PhosphoElm data from PMID 15212693

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SIK1 — STK11 (direct interaction, enzymatic study) Jaleel et al., Biochem J 2006*
• IRef Hprd Interaction: Complex of 61 proteins (in vivo) Al-Hakim et al., J Cell Sci 2005
• IRef Hprd Interaction: Complex of 25 proteins (in vivo) Al-Hakim et al., J Cell Sci 2005

Text-mined interactions from Literome

Takemori et al., Endocr J 2009 : Salt inducible kinase (SIK) 1 , a member of the AMP activated kinase (AMPK) family, is activated by the AMPK-activator LKB1 which phosphorylates SIK1 at Thr182
Cheng et al., Science signaling 2009 (Breast Neoplasms...) : The presence of functional SIK1 was required for the activity of the kinase LKB1 in promoting p53 dependent anoikis and suppressing anchorage independent growth, Matrigel invasion, and metastatic potential
Eneling et al., FASEB J 2012 : Also, LKB1 controls the activity of salt-inducible kinase 1 (SIK1)
Walkinshaw et al., J Biol Chem 2013 : These findings highlight the difference among members of the SIK family and indicate that LKB1 dependent SIK activation constitutes an important signaling module upstream from class IIa deacetylases for regulating cellular programs controlled by MEF2 and other transcription factors