Gene interactions and pathways from curated databases and text-mining

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ICAM1 — RHO

Text-mined interactions from Literome

Adamson et al., J Immunol 1999 : ICAM-1 cross linking results in a reorganization of the endothelial actin cytoskeleton to form stress fibers and activation of the small guanosine triphosphate ( GTP ) -binding protein Rho
Takeuchi et al., Biochem Biophys Res Commun 2000 : Because Rho undergoes geranylgeranyl modification, we elucidated whether Rho is involved in LPS induced ICAM-1 expression
Greenwood et al., J Immunol 2003 : Truncated hICAM-1 proteins were also unable to induce ICAM-1 mediated Rho GTPase activation
Miho et al., Cardiovasc Res 2005 : Dominant negative Ras and Rac1, but not Rho , inhibited thrombin induced JNK activation and ICAM-1 promoter activity
Hirai et al., Biochem Biophys Res Commun 2007 : Small GTPase Rho signaling is involved in beta1 integrin mediated up-regulation of intercellular adhesion molecule 1 and receptor activator of nuclear factor kappaB ligand on osteoblasts and osteoclast maturation ... Our results indicate the direct involvement of Rho mediated signaling in beta1 integrin induced up-regulation of ICAM-1 and RANKL and RANKL dependent osteoclast maturation