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AKT2 — IL4

Text-mined interactions from Literome

Giallourakis et al., J Biol Chem 2000 : However, no differential activation of STAT6, Akt , IRS-2, or p70 ( S6k ), in response to IL-4 , was observed in these cells
Pousset et al., Eur Cytokine Netw 2000 : Furthermore, anti-inflammatory cytokines such as IL-4 and IL-10 that block IL-1b induced NFkappaB activation also attenuate IL-1beta induced Akt phosphorylation, despite the fact that IL-4 and IL-10 in isolation induced Akt phosphorylation
Jiang et al., J Immunol 2001 : In contrast, mutant Fes does not inhibit the activation of Akt by IL-4
Hua et al., Cytokine 2004 : PDGF-BB, but not IL-4 , induced STAT3 tyrosine and AKT serine phosphorylation
Lu et al., Blood 2005 (Lymphoma, B-Cell...) : In contrast, in the ABC-like DLBCL, IL-4 activates AKT , decreases cell proliferation by cell cycle arrest, and does not induce gene expression due to aberrant Janus kinase ( JAK ) -STAT6 signaling attributed to STAT6 dephosphorylation
Fujitsu et al., Invest Ophthalmol Vis Sci 2005 : Both IL-4 and IL-13 induced the phosphorylation of Akt and increased the kinase activity of this enzyme in a manner that was sensitive to the phosphatidylinositol 3-kinase inhibitors LY294002 or wortmannin
Grehan et al., J Immunol 2005 (MAP Kinase Signaling System...) : IL-4 and IL-13 induced rapid phosphorylation of Akt
Bilancio et al., Blood 2006 : p110delta is also critical for interleukin 4 (IL-4) induced phosphorylation of Akt/PKB and FOXO3a, and protection from apoptosis
Jang et al., Cell Immunol 2006 : In fact, IL-4 induced specific activation of NF-kappaB, Akt , and Erk in Jurkat T cells and partially rescued these cells from dexamethasone induced apoptosis
So et al., Mol Immunol 2007 (MAP Kinase Signaling System) : In cytokine producing Jurkat T cells, we have found that IL-4 induces activation of Erk and Akt , and the IL-4 induced STAT6 activity is suppressed by inhibitors of Erk and PI3K
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008 (Hyperglycemia) : Resveratrol inhibits high glucose induced PI3K/Akt/ERK dependent interleukin-17 expression in primary mouse cardiac fibroblasts
Huang et al., Cell Mol Immunol 2008 (Calcium Signaling) : Treatment with Gab2 siRNA significantly decreased Gab2 expression, inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine, reduced the production of IL-4 and TNF-alpha and inhibited the phosphorylation of Akt , PKCdelta and p38 mitogen activated protein kinase ( MAPK )
Feuser et al., Mol Immunol 2011 : The combined challenge of mast cells with IL-4 , SCF and Fc?RI cross linking substantially up-regulated activation of Akt , whereas blocking of Akt inhibited the pronounced production and release of IL-8 in response to the three mast cell agonists
Hosoyama et al., Clin Cancer Res 2011 (Cell Transformation, Neoplastic...) : IL-4 and IL-13 ligands accelerated tumor cell growth and activated STAT6, Akt , or MAPK signaling pathways in the human RMS cell lines, RD and Rh30, as well as in mouse primary ARMS cell cultures
Doroshow et al., Biochem Pharmacol 2012 : Exposure of HT-29 colon cancer cells, which express Nox1, to DPI and DTI confirmed their inhibitory effects on steady state ROS levels, and demonstrated decreased Stat, Erk1/2, and Akt signaling mediated by IL-4 , IL-6, IL-13, and IL-22, possibly due to a concomitant increase in tumor cell phosphatase activity