◀ Back to IL4
ICOS — IL4
Text-mined interactions from Literome
Coyle et al., Immunity 2000
:
We suggest that
ICOS , the third member of the CD28/CTLA-4 family,
plays an important role in production of IL-2,
IL-4 , IL-5, and IFNgamma from recently activated T cells and contributes to T cell dependent B help in vivo
Riley et al., J Immunol 2001
:
Second, on preactivated cells that had high levels of ICOS expression, CTLA-4 ligation blocked the
ICOS mediated
induction of
IL-4 , IL-10, and IL-13, suggesting an interference with downstream signaling pathways
Wahl et al., J Am Soc Nephrol 2002
:
Interestingly,
interleukin-2 production by T cell hybridomas after antigen presentation by TEC was
enhanced by blocking antibodies to B7RP-1 and
ICOS
Feito et al., Eur J Immunol 2003
(MAP Kinase Signaling System) :
The association of phosphoinositide 3-kinase (PI-3K) to H4/ICOS was enhanced by
H4/ICOS cross linking, and PI-3K inhibitors
inhibited ERK and JNK activation and
IL-4/IL-10 secretion, but not p38 MAP kinase or ZAP-70 activation
Okamoto et al., J Rheumatol 2003
(Arthritis, Rheumatoid) :
H4/ICOS costimulation clearly
increased interferon-g,
interleukin 4 (IL-4), and IL-10 production by SF CD4+ T cells
Nurieva et al., Immunity 2003
:
Here we examine the transcriptional mechanisms by which
ICOS regulates Th2 differentiation and selective
IL-4 expression by effector T cells ...
ICOS costimulation
potentiated the T cell receptor ( TcR ) -mediated initial
IL-4 production, possibly through the enhancement of NFATc1 expression ... These data indicate that
ICOS , by enhancing TcR signals at an early stage of T cell activation,
regulates IL-4 transcription and T cell function in effector cells
Yagi et al., J Immunol 2003
:
Conversely, exogenous
IL-4 added to the culture of BALB/c or C57BL/6 naive CD4 ( + ) T cells
up-regulated H4/ICOS expression and IL-4 production upon restimulation
Bellinghausen et al., Immunology 2004
(Hypersensitivity) :
In this system, costimulation of
ICOS strongly
enhanced the production of the T helper 2 cytokines
interleukin (IL)-4 , IL-5 and IL-10 and, to a lesser extent, secretion of the T helper 1 cytokine, interferon-gamma
Wassink et al., J Immunol 2004
:
Previous mouse studies have shown that
IL-4 increases the expression of ICOS on activated Th cells, resulting in enhanced
ICOS expression on Th2 cells ... In this study, we show that
ICOS expression on human Th cells is not
increased by
IL-4 , but by IL-12 and by IL-23 instead
Stanciu et al., J Infect Dis 2006
(Respiratory Syncytial Virus Infections) :
We used flow-cytometric analysis to investigate programmed death-1 ligand (PD-L) 1, PD-L2, B7-H3, and
inducible costimulatory ligand (ICOS-L) expression on tracheal ( NCI-H292 ), bronchial ( BEAS-2B ), and alveolar ( A549 ) epithelial cells ;
regulation of this expression by RSV, interferon (IFN)- gamma, and
interleukin (IL)-4 ; and the effects of IFN-gamma and IL-4 on RSV induced expression of these molecules
Mesturini et al., Eur J Immunol 2006
:
ICOS strikingly
potentiated secretion of IL-2, IFN-gamma, IL-10, and TNF-alpha, but not
IL-4 , promoted by optimal stimulation of CD3+CD28, and it was the key switching-factor of activation when cells received suboptimal stimulation of CD3+CD28 or stimulation of CD3 alone in the presence of exogenous IL-2
Zietara et al., Eur J Immunol 2011
:
NKT-cell proliferation,
IL-4 and IL-13 production induced by MZ B cells were
dependent on
ICOS/ICOS ligand interaction while IFN-? and IL-17 induction by cDCs required glucocorticoid induced TNF receptor/glucocorticoid induced TNF receptor ligand interplay
Hasegawa et al., Rheumatology (Oxford) 2013
(Scleroderma, Diffuse) :
In vitro
ICOS costimulation
enhanced production of IFN-?,
IL-4 and IL-17A from T cells in SSc patients vs normal controls