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MYLIP — SOX2
Text-mined interactions from Literome
Otsubo et al., PloS one 2011
(Cell Transformation, Neoplastic...) :
Gain- and loss-of function experiments and luciferase assays revealed that
miR-126 inhibited
SOX2 expression by targeting two binding sites in the 3'-untranslated region ( 3'-UTR ) of SOX2 mRNA in multiple cell lines
Jeon et al., Cancer Res 2011
(Glioma) :
ID4 imparts chemoresistance and cancer stemness to glioma cells by derepressing
miR-9* mediated suppression of
SOX2 ... Together, our results reveal a novel regulatory mechanism by which ID4-driven suppression of
miR-9* induces
SOX2 , which imparts stemness potential and chemoresistance to glioma cells and GSCs
Yang et al., Biomaterials 2012
(Cell Transformation, Neoplastic...) :
We demonstrated that
miR145 negatively
regulates GBM tumorigenesis by targeting Oct4 and
Sox2 in GBM-CD133 ( + )
Das et al., Oncogene 2013
(Neuroblastoma) :
Although SOX2 contributes to the maintenance of stem cells in an undifferentiated state, we demonstrate that
miR-340 mediated downregulation of
SOX2 is not required for ATRA induced differentiation to occur
Campayo et al., Eur Respir J 2013
:
miR-145 regulates
SOX2 and OCT4 translation and p53 regulates miR-145 expression
Bourguignon et al., J Biol Chem 2012
(Carcinoma, Squamous Cell...) :
Hyaluronan-CD44v3 interaction with
Oct4-Sox2-Nanog promotes
miR-302 expression leading to self-renewal, clonal formation, and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma ... Further analysis reveals that microRNA-302 (miR-302) is controlled by an upstream promoter containing Oct4-Sox2-Nanog binding sites, whereas chromatin immunoprecipitation ( ChIP ) assays demonstrate that stimulation of
miR-302 expression by HA-CD44 is
Oct4-Sox2-Nanog dependent in HNSCC-specific CSCs
Guo et al., Cell Res 2013
(Teratoma) :
Here, we report that
Sox2 directly regulates endogenous microRNA-29b (miR-29b) expression during iPSC generation and that
miR-29b expression is
required for OSKM- and OSK mediated reprogramming
Adammek et al., Fertil Steril 2013
(Endometriosis) :
In all cells investigated,
miR-145 overexpression
inhibited cell proliferation and induced down-regulation of FASCIN-1,
SOX2 , and MSI2