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PTK2 — TNF

Text-mined interactions from Literome

Shames et al., J Surg Res 1999 : LPS Induced NF-kappaB activation and TNF-alpha release in human monocytes are protein tyrosine kinase dependent and protein kinase C independent ... PTK inhibition with Gen attenuated both LPS induced NF-kappaB DNA binding and TNF-alpha production in human monocytes ... Furthermore, our results provide evidence that PTK plays a role in LPS induced NF-kappaB activation and TNF-alpha release in human monocytes and thus could be a potential therapeutic target in inflammatory states
Boussouar et al., Endocrinology 1999 : These observations suggest that the stimulatory effect of TNFalpha on LDH A mRNA expression requires protein synthesis and may involve a protein tyrosine kinase and protein kinase C
Lin et al., J Immunol 2000 : OX8 ( CD8 alpha ) -induced TNF and IL-1 beta production by macrophages was blocked by inhibitors of protein tyrosine kinase ( s ), PP1, and genistein, but not by phosphatidylinositol-3 kinase inhibitor, wortmannin
Rojas et al., Cell Immunol 2002 : Inhibitors of PTK ( AG-126 ), or JAK2 ( AG-490 ) inhibited TNF-alpha and NO production, caspase 1 activation and apoptosis, suggesting that M. tuberculosis-induction of these events depends on JAK2/STAT1-alpha activation
Trajkovic et al., Infect Immun 2002 : The activation of protein tyrosine kinases ( PTK ) and the serine/threonine kinases p38 MAPK and ERK was apparently required for MTSA-10 induction of TNF-alpha and NO release, as revealed by specific kinase inhibitors
Hasan et al., Tuberculosis (Edinb) 2003 (MAP Kinase Signaling System) : TNF alpha production involved the PTK and MAP kinase pathways
Dewas et al., J Immunol 2003 : These findings show that TNF-alpha , via its p55 receptor, induces a protein tyrosine kinase dependent selective phosphorylation of p47(phox) on specific serines
Suzuki et al., J Neurosci 2004 : Together, these findings indicate that both ERK and JNK are involved in the regulation of TNF mRNA expression, that p38 is involved in the nucleocytoplasmic transport of TNF mRNA, and that a PTK ( protein tyrosine kinase ), possibly a member of the src family, acts downstream of the P2X7 receptor to activate JNK and p38
Takada et al., J Immunol 2004 : TNF activates Syk protein tyrosine kinase leading to TNF induced MAPK activation, NF-kappaB activation, and apoptosis
Raung et al., Biochem Biophys Res Commun 2005 (Encephalitis, Japanese) : PTK inhibitors suppressed JEV induced TNF-alpha and IL-1beta production at the transcriptional level
Doisne et al., Mol Immunol 2008 (Inflammation) : Pharmacological disruption of lipid rafts microdomains abolished the assembly of HLA-DR/CD18/PTK signaling complex, HLA-DR mediated tyrosine activation, and the PTK dependent TNFalpha expression in IFNgamma primed THP-1 cells
Cheon et al., Exp Mol Med 2007 (MAP Kinase Signaling System) : Genistein, a protein tyrosine kinase ( PTK ) inhibitor, and PD153035, an EGFR inhibitor, also blocked the increase of TNF-alpha expression by TCDD, indicating the role of EGFR in TCDD induced TNF-alpha expression
Shapira et al., J Immunol 1994 : Involvement of protein kinase C and protein tyrosine kinase in lipopolysaccharide induced TNF-alpha and IL-1 beta production by human monocytes ... The results suggest that TNF-alpha and IL-1 beta secretion after LPS stimulation of human monocytes requires the activation of protein tyrosine kinase and PKC, upstream to the activation of gene transcription
Berton et al., J Cell Biol 1994 : We found that the fgr protein-tyrosine kinase ( p58fgr ) activity, and its extent of phosphorylation in tyrosine, in PMN adherent to fibrinogen, was enhanced by TNF
Sasaki et al., Proc Soc Exp Biol Med 1995 : These findings suggest that, in TNF-resistant cells, TNF activates a protein tyrosine kinase that contributes to the cell 's resistance to lysis and this resistance mechanism does not function in the TNF-sensitive cell line
Lepidi et al., Int J Immunopharmacol 1994 : The role of protein tyrosine kinases ( PTK ) in TNF alpha secretion by human monocytes was investigated in this report
al-Daccak et al., Infect Immun 1994 (Arthritis, Infectious...) : Finally, our results, obtained with protein tyrosine kinase inhibitors and antiphosphotyrosine Western blotting ( immunoblotting ), indicate that protein tyrosine kinase is involved in MAM induced IL-1 beta and TNF-alpha gene expression in the THP-1 monocytic cell line
Trede et al., Clin Immunol Immunopathol 1994 : PTK and PKC activation plays a role in the induction of monokine gene transcription by SE because inhibitors of PTK and PKC reduced TSST-1 stimulated IL-1 beta and TNF-alpha gene expression
Mattsson et al., J Infect Dis 1996 : The results obtained with other modulatory substances, including different protein kinase and G protein inhibitors, suggest that calmodulin dependent protein kinase, protein tyrosine kinase , and a cholera-toxin-sensitive G protein are involved in both PG- and LPS induced TNF-alpha release
Callaghan et al., J Leukoc Biol 1996 (Leukemia, Myelomonocytic, Acute) : Additionally, TNF-alpha induced PTK and NF-kappa B activation were important in collagenase gene expression in this cell line
Meisel et al., Eur J Immunol 1996 : LPS induced TNF-alpha and IL-10 expression requires early activation of protein tyrosine kinases ( PTK )
Renier et al., Endocrinology 1996 : Addition of these compounds resulted in a dose dependent inhibition of the stimulatory effect of IGF-I on macrophage TNF alpha release, indicating that protein tyrosine kinase activation is required for TNF alpha stimulation by IGF-I
Kong et al., Neurochem Int 1997 : This study examined the effects of two potent protein tyrosine kinase inhibitors, genistein and tyrphostin A25, on lipopolysaccharide (LPS) induced production of TNF alpha , IL-1 alpha, and IL-6 in mouse primary mixed glia, microglia- or astrocyte enriched cultures
Su et al., J Immunol 1997 (Leukemia, Promyelocytic, Acute) : The release of URO and THP induced TNF-alpha in monocytes was dependent upon protein tyrosine kinase activation that results in tyrosine phosphorylation
Nishinarita et al., Nihon Rinsho Meneki Gakkai Kaishi 1997 : The results suggest that PTK is required for FN-stimulated TNF-alpha secretion ... Therefore, both PTK and PKC may be involved in LPS stimulated TNF-alpha secretion
Simms et al., Ann Surg 1997 : Modulation of IL-1 beta and TNF-alpha receptors by VLA-5 and VLA-6 required protein tyrosine kinase activation as herbimycin A ( 10 micrograms/mL ) blocked the affect of Fn and Ln. Changes in PMN cytokine receptor expression led to parallel changes in functional activity as assessed by the binding of 125I IL-1 beta and TNF-alpha
Lichtman et al., J Leukoc Biol 1998 : The inhibitor of PTK , tyrphostin AG, blocked TNF-alpha release by only 39 +/- 4 % ( P < 0.001 compared with TNF-alpha release when added simultaneously with LPS ) when added 10 min after LPS