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DDX58 — ISG15

Pathways - manually collected, often from reviews:

• KEGG RIG-I-like receptor signaling pathway: ISG15 → DDX58 (protein-protein, binding/association)
• Reactome Reaction: ISG15 → DDX58 (indirect_complex) Kim et al., J Virol 2008*
• Reactome Reaction: ISG15 → DDX58 (reaction) Kim et al., J Virol 2008*
• WikiPathways RIG-I-like Receptor Signaling: ISG15 → DDX58 (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: ISG15 — DDX58 (physical association, affinity chromatography technology) Zhao et al., Proc Natl Acad Sci U S A 2005
• IRef Biogrid Interaction: ISG15 — DDX58 (physical association, affinity chromatography technology) Arimoto et al., Mol Immunol 2008*

Text-mined interactions from Literome

Imaizumi et al., Am J Nephrol 2013 : Using an RNA interfering technique, involvement of TLR3, IFN-ß, melanoma differentiation associated gene 5 ( MDA5 ) or retinoic acid-inducible gene-I (RIG-I) in ISG56 expression, and of ISG56 in the expression of MDA5, RIG-I , CXCL10 and CCL5 was examined ... ISG56 is involved in the expression of MDA5, RIG-I , CXCL10 and CCL5, and ISG56 and MDA5 may constitute a positive-feedback loop
Langevin et al., J Virol 2013 : Additionally, zf-ISG15 overexpression triggers induction of the rig-I and viperin genes as well as, to a lesser extent, the IFN gene