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APLN — EPHB2

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Bai et al., Acta Biochim Biophys Sin (Shanghai) 2008 : Apelin-13 induces ERK1/2 but not p38 MAPK activation through coupling of the human apelin receptor to the Gi2 pathway ... Here, using stably transfected human embryonic kidney 293 (HEK293) cells overexpressing human APJ ( HEK293-apelinR ), we showed that apelin-13 signaling leads to ERK1/2 and p38 MAPK pathways through APJ activation ... It was found in HEK293-apelinR cells that ERK1/2 activation was initiated by apelin-13 at 5 min, with the peak of activation occurring at 15 min, and a return to the basal level within 60 min ... We also shown that the apelin-13 induced ERK1/2 activation requires a coupling with pertussis toxin-sensitive G-protein, and that overexpression of dominant negative Gi2 completely inhibits the apelin-13 induced ERK1/2 activation ... In conclusion, the ERK1/2 , but not p38 MAPK pathway is activated by apelin-13 through coupling of human APJ to Gi2-protein, which contributes to cellular responses
Cui et al., Amino Acids 2010 : Suppression of APJ with siRNA abolished the apelin induced activation of ERK and Akt
Liu et al., Acta Biochim Biophys Sin (Shanghai) 2010 : PI3K inhibitor LY294002 significantly decreased the expression of phospho-PI3K, phospho-Akt, phospho-ERK1/2 , and cyclin D1 induced by apelin-13