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EPHB2 — RAF1

Text-mined interactions from Literome

Ozaki et al., J Biol Chem 1999 : Upstream of ERK , Shc was shown to be activated, but its downstream Raf1 and ERK were inhibited
Huang et al., Oncogene 1999 : Taxol induced apoptosis was associated with phosphorylation of both c-Raf-1 and Bcl-2 and activation of ERK and JNK MAP kinases
English et al., J Biol Chem 1999 (Cell Transformation, Neoplastic) : We found that Raf-1 does contribute to Ras activation of ERK5 but in a manner that does not correlate with Raf-1 catalytic activity
DeFea et al., J Cell Biol 2000 : The complex, which contains internalized receptor, beta-arrestin, raf-1 , and activated ERK, is required for ERK1/2 activation
Piiper et al., Mol Pharmacol 2000 : PTx also inhibited ERK1/2 activation in response to the PKC activator 12-O-tetradecanoylphorbol-13-acetate ( TPA ) and epidermal growth factor (EGF) as well as activation of c-Raf-1 by EGF and CCK
Florio et al., J Physiol Paris 2000 (MAP Kinase Signaling System) : We show that the activation of ERK via SSTR1 is mediated by the betagamma subunit of a pertussis toxin-sensitive G-protein and requires both the small G protein Ras and the serine/threonine kinase Raf-1
Luttrell et al., Proc Natl Acad Sci U S A 2001 : The phosphorylation of ERK2 in beta-arrestin complexes was markedly enhanced by coexpression of cRaf-1 , and this effect is blocked by expression of a catalytically inactive dominant inhibitory mutant of MEK1
Reusch et al., J Biol Chem 2001 : Pertussis toxin, N17-Ras/Raf , and PD98059 prevented both the serum- and thrombin induced second phase ERK phosphorylation and SM-MHC promoter activation
Kampfer et al., J Biol Chem 2001 : Expression of kinase-defective, dominant negative ( DN ) mutants of nPKC-epsilon or aPKC-zeta inhibit ERK activation by constitutively active Raf-1
Fernandez-Patron et al., FASEB J 2001 (MAP Kinase Signaling System) : Stimulation of Erk activity was due to activation of Ras, Raf-1 , and MEK ( MAPK kinase )
Tohgo et al., J Biol Chem 2002 (MAP Kinase Signaling System) : beta-Arrestin overexpression resulted in formation of a cytoplasmic pool of beta-arrestin bound phospho-ERK, decreased nuclear translocation of phospho-ERK1/2, and inhibition of Elk1-driven luciferase transcription even when ERK1/2 was activated by overexpression of cRaf-1 in the absence of AT1aR stimulation
Chan et al., Mol Carcinog 2002 (Cell Transformation, Neoplastic...) : Expression of G361S Raf-1 in Rat2 fibroblasts activated MEK and ERK
Correa-Meyer et al., Am J Physiol Lung Cell Mol Physiol 2002 (MAP Kinase Signaling System) : The inhibition of Grb2-SOS interaction with an SH3 binding sequence peptide, Ras with a farnesyl transferase inhibitor, and Raf-1 with forskolin did not affect the stretch induced ERK1/2 phosphorylation
Dhillon et al., Mol Cell Biol 2002 : Using RafS259 mutants we also demonstrate that Raf-1 is the sole target for PKA inhibition of ERK and ERK induced gene expression, and that Raf-1 inhibition is mediated mainly through serine 259 phosphorylation
Nadal-Wollbold et al., FEBS Lett 2002 : Platelet ERK2 activation by thrombin is dependent on calcium and conventional protein kinases C but not Raf-1 or B-Raf
Norum et al., J Biol Chem 2003 (MAP Kinase Signaling System) : ERK1/2 activation was reduced in the presence of `` dominant negative '' Raf1 ( RafS621A ) and slightly reduced by dominant negative B-Raf, indicating the involvement of one or more Raf isoforms
Miura et al., Biochem Biophys Res Commun 2003 : These results demonstrate that Ras/Raf1 dependent ERK activation mediated by PTX-sensitive G protein coupled receptors may be a potent signal in S1P induced HCEC tube formation
Sippel et al., Am J Physiol Gastrointest Liver Physiol 2003 (Carcinoid Tumor...) : Activation of raf-1 in BON-raf cells led to a marked induction of phosphorylated MEK and ERK1/2 within 48 h. Importantly, raf-1 activation resulted in morphological changes accompanied by a marked decrease in neuroendocrine secretory granules by electronmicroscopy ... Furthermore, treatment of BON-raf cells with MEK inhibitors PD-98059 and U-0126 blocked raf-1 mediated morphological changes and hormone suppression but not ERK1/2 phosphorylation
Cerioni et al., FEBS Lett 2003 (Adrenal Gland Neoplasms...) : These results, along with others obtained using respiratory chain inhibitors and respiration-deficient cells, lead to the conclusion that PD98059, while effectively inhibiting the peroxynitrite induced Raf/MEK signaling leading to ERK1/2 phosphorylation, promotes an enforced mitochondrial formation of ROS inducing ERK1/2 phosphorylation via a Raf-1-independent/MEK dependent mechanism
Illario et al., J Biol Chem 2003 : This is the first demonstration that CaMKII interplays with Raf-1 and regulates Erk activation induced by Ras stimulated Raf-1
Kamata et al., Blood 2004 (Thrombocytopenia) : Raf-1 is not required for megakaryocytopoiesis or TPO induced ERK phosphorylation
Sippel et al., Surgery 2003 (Carcinoma, Medullary...) : Activation of raf-1 in the TT-raf cells resulted in high levels of phosphorylated MEK and ERK1/2 , a morphologic transdifferentiation, and a decrease in chromogranin A and calcitonin levels that are associated with a reduction in hASH1 production
Clark et al., J Biol Chem 2004 (MAP Kinase Signaling System) : PKC/PKC alpha activity promoted GTP loading of Ras, activation of Raf-1 , and phosphorylation/activation of ERK
Su et al., J Biol Chem 2004 (Chlamydia Infections) : Blocking either c-Raf-1 or MEK1/2 activity prevented the chlamydial activation of ERK1/2 , leading to the suppression of both chlamydial activation of the host cPLA2 and uptake of glycerophospholipids from the host cells
Schattenberg et al., Hepatology 2004 (MAP Kinase Signaling System) : CYP2E1 expression induced ERK1/2 activation through increased epidermal growth factor receptor (EGFR)/c-Raf signaling
Rössler et al., J Neurochem 2004 : Activation of this conditionally active form of Raf-1 induced a sustained phosphorylation of ERK , and protected the cells from serum withdrawal induced cell death
Keller et al., Biochem Pharmacol 2004 (Neoplasms) : Protein kinase C ( PKC ) phosphorylates RKIP, resulting in release of Raf-1 and activation of MEK and ERK
Torres et al., Nephron. Experimental nephrology 2004 (Polycystic Kidney Diseases) : While cAMP inhibits Ras-Raf-1 stimulated phosphorylation of ERK in normal kidney cells, it markedly increases B-Raf kinase activity and ERK phosphorylation in polycystic kidney cells
Wang et al., J Cell Physiol 2005 (Liver Neoplasms, Experimental...) : The suppression of Raf-1 Ser-259 phosphorylation caused the induction of Raf-1 kinase activity, as well as hyper-ERK phosphorylation
Krepinsky et al., Cell Signal 2005 : The Raf-1 inhibitor, GW5074, dose-dependently blocked strain induced Erk activation and Raf-1 phosphorylation
Mariappan et al., J Biol Chem 2005 : Studies with PP1/2 showed that phosphorylation of c-Src was required for tyrosine phosphorylation of Raf-1 , an upstream regulator of Erk
Calipel et al., J Biol Chem 2006 (Cell Transformation, Neoplastic...) : siRNA mediated depletion of Raf-1 did not affect either ERK1/2 activation, whereas siRNA mediated depletion of B-Raf reduced cell proliferation by up to 65 % through the inhibition of ERK1/2 activation, irrespective of the mutational status of B-Raf
Raines et al., Biochem J 2006 : In contrast, exogenous expression of constitutively active mutants of Raf-1 and H-Ras only partially restored ERK1/2 activity, by 50 % and 10 % respectively
Sánchez-Tilló et al., J Immunol 2006 : However, whereas ERK phosphorylation in response to M-CSF is Raf-1 dependent , in response to LPS, an alternative pathway directs the activation of these kinases
Lee et al., Am J Physiol Heart Circ Physiol 2006 (Inflammation...) : However, inhibitors of Raf-1 and MEK or a dominant negative ERK mutant blocked FKN induced ERK , but not Akt and eNOS, phosphorylation
Wang et al., J Cell Physiol 2006 : In late stage differentiating cells Raf-1 and p90RSK are found as a complex, and inhibition of Raf-1, but not MEK or ERK expression reduces the levels of phosphorylated p90 RSK
Marzec et al., Oncogene 2007 (MAP Kinase Signaling System) : The NPM/ALK induced MEK/ERK activation is independent of c-Raf as evidenced by the lack of MEK1/2 and ERK1/2 phosphorylation upon c-Raf inactivation by two different inhibitors, RI and ZM336372, and by its siRNA mediated depletion
Kohda et al., J Toxicol Sci 2006 : The Raf-1 kinase inhibitor and U0126 also suppressed ERK1/2 activation in nuclear fractions prepared from slices treated with zinc
Kogut et al., Mol Immunol 2007 : The classic Ras mediated pathway of ERK1/2 activation by LPS was confirmed when the specific Raf-1 inhibitor, GW 5074, and the MEK1/2 inhibitor, U0126, both reduced ERK activation by 51-60 %
Kanno et al., J Cell Biochem 2007 (MAP Kinase Signaling System) : These findings indicate that mechanical stress regulates Runx2 activation and favors osteoblast differentiation through the activation of MAPK signal transduction pathways and Ras/Raf dependent ERK1/2 activation, independent of p38 MAPK signaling
Golding et al., Cancer Res 2007 (Glioma...) : When ERK1/2 signaling was stimulated by oncogenic RAF-1 , an approximately 2-fold increase in HRR was observed
Morishita et al., Neurosci Res 2007 : Endothelin induced ERK phosphorylation was independent of integrin ligands, and an inhibitor of G ( q/11 ), YM-254890, as well as pertussis toxin, partially inhibited endothelin stimulated phosphorylation of Raf-1 and ERK
Galabova-Kovacs et al., J Cell Biol 2008 (MAP Kinase Signaling System) : In B-Raf-deficient cells, more Raf-1 is recruited to MEK, yet MEK/ERK phosphorylation is impaired
Gerits et al., Cell Signal 2008 : The first- and best characterized interconnections are the PKA dependent inhibition of the MAPKs ERK1/2 mediated by RAF-1 , and PKA induced activation of ERK1/2 interceded through B-RAF
Lai et al., Cell Biochem Funct 2009 : Our results suggest that rapid PTH inhibition of ERK1/2 activity is mediated by PKA dependent inhibition of c-Raf activity and that stimulation of MKP-1 may contribute to maintaining pERK1/2 inhibition over prolonged time
Zhao et al., Proc Natl Acad Sci U S A 2011 (Asthma...) : MAPK kinase ( MEK ) /ERK activation is regulated by interactions of Raf-1 with phosphatidylethanolamine binding protein 1 ( PEBP1 ) ... siRNA knockdown of 15LO1 decreases the dissociation of Raf-1 from PEBP1, and the resulting lower ERK activation leads to lower downstream IL-4Ra related gene expression
Mor et al., Am J Physiol Cell Physiol 2012 (MAP Kinase Signaling System) : Coexpression of ZnT-1 and nonactive Raf-1 blocked the ZnT-1 mediated ERK phosphorylation and abolished the ZnT-1 induced augmentation of I ( caT )
Hutchison et al., Mol Endocrinol 2012 (MAP Kinase Signaling System) : This work describes a model wherein unopposed IGF-I promotes high ERK/p38 activity ratios favoring proliferation, whereas BDNF signals a transition to differentiation by decreasing the ERK/p38 activity ratio without completely inhibiting ERK , which involves the direct inhibition of raf-1 by p38
Amatangelo et al., Carcinogenesis 2012 (Prostatic Neoplasms) : Mechanistic studies revealed that in cells stably transfected with activated Ras, TGF-ß alone induced EMT and that a Ras-Raf-MEK1 , but not MEK2, signaling cascade is necessary and sufficient for Erk2 nuclear localization that works in concert with TGF-ß to promote EMT
Wu et al., Mol Cell Biol 2012 (MAP Kinase Signaling System...) : Furthermore, kinase activating RAF1 mutants also required heterodimerization to enhance MEK/ERK activation
Atabakhsh et al., PloS one 2012 (Cell Transformation, Neoplastic...) : Activation of ERK by active c-Raf was also prevented by RanBPM
Li et al., Cell Physiol Biochem 2012 (Acute Lung Injury...) : Inhibition of Src or Raf-1 blocked LPS induced ERK activation
Deswal et al., J Immunol 2013 : Although Raf-1 triggers transient Erk activation, B-Raf is implicated in sustained Erk signaling after TCR stimulation
Blume-Jensen et al., J Biol Chem 1994 : SCF induced phosphorylation of Raf-1 and activation of ERK2 still occurred after PKC inhibition but was not increased
Lisbona et al., Eur J Immunol 1994 : We also show that ERK kinase activation precedes Raf-1 kinase hyperphosphorylation, suggesting that Raf-1 kinase activation is not required for ERK kinase activation
Minden et al., Science 1994 : Raf-1 contributes directly to ERK activation but not to JNK activation, whereas MEKK participated in JNK activation but caused ERK activation only after overexpression
Izquierdo et al., J Exp Med 1994 : In the present study, the role of Raf-1 in ERK2 regulation of ERK2 in T cells has been explored ... These data indicate a role for Raf-1 in the regulation of ERK2 in T cells
Marrero et al., J Biol Chem 1997 : AG-490, a specific inhibitor of the JAK2 tyrosine kinase, prevented proliferation of vascular smooth muscle cells, complex formation between JAK2 and Raf-1, the tyrosine phosphorylation of Raf-1 , and the activation of ERK1 in response to either angiotensin II or platelet derived growth factor
Carson-Walter et al., Oncogene 1998 (Carcinoma, Medullary...) : We now show that raf-1 induction is followed by activation of the downstream kinases MEK1/2 and ERK1/2 and that differentiation is dependent on activation of MEK1/2
Florio et al., Mol Endocrinol 1999 : We show that the activation of ERK via SSTR1 is pertussis toxin sensitive and requires the small G protein Ras, phosphatidylinositol 3-kinase, the serine/threonine kinase Raf-1 , and the protein tyrosine phosphatase SHP-2