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HMOX1 — RNF19A
Text-mined interactions from Literome
Brouard et al., J Exp Med 2000
:
Expression of
HO-1 or exposure of ECs to exogenous CO
enhanced p38 MAPK activation by TNF-alpha
Wijayanti et al., J Biol Chem 2005
(Inflammation) :
Inhibition of
p38alpha and p38beta, but not that of JNK or p38gamma and p38delta,
prevented the induction of
HO-1 gene expression by AEBSF
Rushworth et al., Biochem Biophys Res Commun 2006
:
Furthermore, a
p38 MAP kinase inhibitor
reduced GCLM and
HO-1 expression and rottlerin inhibited curcumin induced p38 phosphorylation
McNally et al., Int J Mol Med 2007
:
PKC and
p38 MAPK activity are
required for full induction of
HO-1
Liu et al., Cardiovasc Res 2007
(Atherosclerosis) :
BHA mediated
HO-1 expression was
dependent on the activation of NF-E2 related factor-2 by
p38 mitogen activated protein kinase
Hsu et al., Am J Physiol Regul Integr Comp Physiol 2008
(Hemorrhage...) :
p38 MAPK activation also
results in the induction of
heme oxygenase (HO)-1 , which exerts potent anti-inflammatory effects ... This was accompanied with a decrease in intestinal
p38 MAPK activity and
increase in
HO-1 expression
Min et al., J Endod 2008
(MAP Kinase Signaling System) :
Antioxidants and inhibitors of HO-1, phosphatidylinositol-3'-kinase, extracellular signal regulated kinase, and
p38 mitogen activated protein kinase
blocked H2O2 induced cytotoxicity and the expression of
HO-1 and DSPP mRNA in pulp cells
Guan et al., J Cell Biochem 2008
(MAP Kinase Signaling System) :
The
p38 mitogen activated protein kinase pathway is
involved in the regulation of
heme oxygenase-1 by acidic extracellular pH in aortic smooth muscle cells
De Backer et al., Gut 2009
(Ileus...) :
These protective effects are, at least in part, mediated through induction of
HO-1 , in a
p38 dependent manner, as well as reduction of ERK1/2 activation
Huang et al., Toxicol Appl Pharmacol 2009
:
Inhibition of the
p38 mitogen activated protein kinase pathway significantly
blocked HO-1 induction by METH and aggravated METH neurotoxicity
Ohnishi et al., Brain Res 2010
(Brain Injuries...) :
Overall, these results suggest that
p38 MAPK dependent
induction of
HO-1 supports survival of striatal microglia during thrombin insults
Rojo et al., Free Radic Biol Med 2012
:
By using selective kinase inhibitors we found that PI3K, JNK, and
p38 were
responsible for the stabilization of Nrf2 and induction of
HO-1 by NDGA
Jin et al., Environ Toxicol Pharmacol 2012
:
Finally, a specific inhibitor of
p38 reduced BCE induced
HO-1 expression and BCE induced phosphorylation of p38 MAPK
Kästle et al., Free Radic Biol Med 2012
(MAP Kinase Signaling System) :
In this study we demonstrate that the up-regulation of
HO-1 on proteasome inhibition is
mediated by
p38MAPK and Nrf-2