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CLEC7A — IL12B

Text-mined interactions from Literome

Harada et al., Microbiol Immunol 2006 (Leukopenia) : Blocking dectin-1 significantly inhibited the induction of TNF-alpha and IL-12p70 production by SCG
Manicassamy et al., Nat Med 2009 : In contrast, dectin-1 signaling mostly induced IL-23 and proinflammatory cytokines and augmented T ( H ) 17 and T ( H ) 1-mediated autoimmune responses in vivo
Huang et al., Infect Immun 2009 : The upregulation of TNF-alpha and downregulation of IL-12p70 required Dectin-1 , but not IL-10
Chaung et al., Vet Immunol Immunopathol 2009 : Zymosan enhanced dectin-1/TLR2/TLR4 expression and TNF-alpha/IL-10 production in all of three types of cell, whereas p-beta-glucan increased dectin-1/TLR4 and TNF-alpha/IL-12 production in AMs but inhibited IL-10 in mDCs
Rivera et al., J Exp Med 2011 (Aspergillosis) : Dectin-1 signaling in A. fumigatus infected wild-type mice reduces IFN-? and IL-12p40 expression in the lung, thereby decreasing T-bet expression in responding CD4 T cells and enhancing Th17 responses
Salazar-Aldrete et al., J Clin Immunol 2013 (Arthritis, Rheumatoid...) : In addition, cells from SLE patients showed an abnormal calcium flux response induced by dectin-1 ligands as well as an enhanced release of IL-1ß, IL-6 and TNF-a, but not IL-23 , upon dectin-1 engagement
Mintz-Cole et al., J Allergy Clin Immunol 2013 (Asthma) : Furthermore, the production of TH17 skewing IL-6, IL-23 , and TNF-a by dendritic cells in response to heat killed C cladosporioides was dependent on Dectin-1