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TLR2 — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TLR2 → TNF (increases)
  Evidence: Next, it was shown that in the presence of LPS or TNF-?, endothelial cell TLR2 protein and mRNA markedly increased in cells exposed to static conditions relative to cells exposed to laminar flow.
• OpenBEL Selventa BEL large corpus: TLR2 → TNF (increases)
  Evidence: Type-1 cytokines including IL-1?, TNF-? and IFN-? induced a strong up-regulation of TLR2 mRNA (Fig. 8) and protein expression that was most pronounced by the co-stimulation with TNF-? and IFN-? (Fig. 5).

Text-mined interactions from Literome

Underhill et al., Proc Natl Acad Sci U S A 1999 : We identify toll-like receptor-2 (TLR2) as the specific toll-like receptor required for this induction by showing that expression of an inhibitory TLR2 ( TLR2-P681H ) blocks TNF-alpha production induced by whole M. tuberculosis ... Thus, although many mycobacterial cell wall fractions are identified to be inflammatory, all require TLR2 for induction of TNF-alpha in macrophages
Faure et al., J Immunol 2001 (Inflammation...) : Here we show that LPS, TNF-alpha , or IFN-gamma induce TLR2 expression in both human dermal microvessel EC and HUVEC
Means et al., J Immunol 2001 (Tuberculosis) : Together, these data suggest that Mtb induced TNF-alpha production is largely dependent on TLR signaling
Flo et al., J Leukoc Biol 2001 : On purified granulocytes, LPS, GM-CSF, and TNF down-regulated, and IL-10 modestly increased TLR2 expression after 2 h
Iwadou et al., J Int Med Res 2002 (Gram-Negative Bacterial Infections...) : The results suggest that gabexate mesilate induced inhibition of tumour necrosis factor-alpha (TNF-alpha) and interleukin-18 (IL-18) production in LPS stimulated PBMCs is due to the inhibition of the nuclear factor-kappa B activation pathway and/or inhibition of the processing pathway of pro-TNF-alpha and pro-IL-18, not to down-regulation of TLR-2 or TLR-4
Wang et al., J Biol Chem 2002 (MAP Kinase Signaling System) : Furthermore, a specific TLR2 blocking monoclonal antibody ( 2392 ) attenuated BLP induced, but not LPS induced, tumor necrosis factor-alpha and interleukin-6 production, indicating BLP rather than LPS as a ligand for TLR2 engagement and activation
Takami et al., J Immunol 2002 : Moreover, various TLR ligands ( e.g., peptidoglycan, poly ( I:C ) dsRNA, LPS, and CpG motif of unmethylated DNA, which act as ligands for TLR2, 3, 4, and 9, respectively ) induced NF-kappa B activation and up-regulated TNF-alpha production in osteoclast precursor cells
Riordan et al., Hepatology 2003 (Liver Cirrhosis) : TLR2 likely contributes to increased circulating TNF-alpha and sTNFR levels in cirrhosis
Oshikawa et al., Biochem Biophys Res Commun 2003 (Lung Diseases) : The results demonstrated three patterns of gene expression : the TLR2 and myeloid differentiation factor 88 ( MyD88 ) gene expressions were induced in AM in response to lipopolysaccharide (LPS), interleukin (IL)-1beta, or tumor necrosis factor-alpha or in the lung tissue of an LPS induced acute lung injury model ; the gene expressions of TLR1, -3, -6, CD14, and MD2 were unchanged ; and the TLR4 and TLR5 gene expressions were downregulated in AM following inflammatory stimuli
Huang et al., J Immunol 2003 : Taken together, our data demonstrate that MyD88 dependent pathways are crucial for activation by HKBA and that TLR2 plays a role in TNF , but not IL-12p40 pathways activated by this microbial product
Pinhal-Enfield et al., Am J Pathol 2003 : C57BL/10ScN ( TLR4 deletion mutant ) macrophages produce TNFalpha in response to TLR2 , 3, 7, and 9 agonists, but not the TLR4 agonist E. coli LPS ... While adenosine and A ( 2A ) R agonists strongly down-regulate TNFalpha protein expression induced by TLR2 , 3, 4, 7, and 9 agonists, TNFalpha mRNA and NF-kappaB activation are not reduced
Lucas et al., J Immunol 2003 : TLR ligands induced early and sustained secretion of TNF-alpha , macrophage-inflammatory protein (MIP) 1alpha and MIP-2 with later secretion of IL-10, IL-12, and TGF-beta1 ; apoptotic cells alone stimulated late TGF-beta1 secretion only
Farina et al., Int Immunol 2004 : In response to TLR-2 , -4 and -5 engagement, approximately 50 % of monocytes produced TNF-alpha , compared to only 5 % after induction with IFN-gamma or GM-CSF
Gehring et al., J Immunol 2004 : Short-term exposure ( < 6 h ) to LprG stimulated TLR-2 dependent TNF-alpha production
Dolganiuc et al., Gastroenterology 2004 (Hepatitis C...) : The hyper elevated TNF-alpha induction by TLR2 ligands in monocytes of HCV infected patients was not due to increased TLR2 expression
Li et al., Biochem Biophys Res Commun 2004 : These signals are required for optimal production of TNFalpha in response to TLR2 stimulation, and are absent in macrophages from TLR4 mutant animals
Goral et al., J Immunol 2005 (Inflammation) : Furthermore, different TLR ligands stimulated IL-6 and TNF-alpha production via signaling pathways, which showed unique characteristics
Muthukuru et al., Infect Immun 2005 (Chronic Disease...) : However, restimulation of MC with either PgLPS or EcLPS downregulates TLR2 and TLR4 mRNA and protein and IL-1beta mRNA and induces a ca. 10-fold reduction in TNF-alpha secretion, suggesting the induction of endotoxin tolerance by either LPS
Murphy et al., J Immunol 2005 (Burns) : We first compared the relative changes in TLR4- and TLR2 induced TNF-alpha , IL-1beta, and IL-6 production by spleen cell populations prepared from wild-type ( WT ), Rag1 ( -/- ), CD4 ( -/- ), or CD8 ( -/- ) mice 7 days after sham or burn injury
Maldonado-Bernal et al., Parasite Immunol 2005 : The interaction of LPPG with TLR2 and TLR4 resulted in activation of NF-kappaB and release of interleukin (IL)-10, IL-12p40, tumour necrosis factor (TNF)-alpha , and IL-8 from human monocytes
Levy et al., J Endotoxin Res 2005 : Differences between newborns and adults with respect to TLR induced TNF-alpha release extend to a range of TLR agonists, including bacterial lipopeptides, and are due to differences in soluble factors present in blood plasma ... Soluble factors in neonatal blood plasma suppress TLR induced TNF-alpha release from monocytes and efforts to identify and characterize these inhibitors are on-going
Gibson et al., J Biol Chem 2005 (Inflammation) : SaeLM induced a Toll-like receptor 2 (TLR-2) dependent production of tumor necrosis factor-alpha (TNF-alpha) by human THP-1 monocyte/macrophage cell lines and interestingly was found to be the strongest inducer of this pro-inflammatory cytokine when compared with other LAM/LM-like molecules
Suliman et al., FASEB J 2005 : In wild-type ( Wt ) mice injected with heat inactivated E. coli, hepatic TLR4 and TLR2 proteins were up-regulated with TLR dependent increases in transcript levels for tumor necrosis factor ( TNF-alpha ), interleukin 6, nitric oxide synthase-II ( iNOS ), and NADPH oxidase 2 (Nox2)
Shi et al., J Immunol 2005 : TLR2 mediates the responses of a numerically minor set of genes that collectively do not appear to affect the course of infection in mice ; regulation of TNF requires TLR2/4 for post-transcriptional control, but not for transcriptional induction ; and many responding genes are regulated through an unknown, TLR2/4 independent pathway that may involve IFN-alphabetaR and STAT1
Fan et al., Am J Physiol Lung Cell Mol Physiol 2006 (Pneumonia...) : The enhanced TLR2 upregulation in AMphi augmented the expression of macrophage inflammatory protein-2, TNF-alpha , and macrophage migration inhibitory factor in the AMphi in response to sequential challenges of LPS and peptidoglycan, a prototypical TLR2 ligand, which physiologically associated with amplified AMphi induced PMN migration into air pouch and lung alveoli
Flandin et al., Eur J Immunol 2006 (Inflammation...) : Silencing of TLR3, TLR2, IRAK-1 and myeloid differentiation factor 88 ( MyD88 ) expression by RNA interference revealed that both TLR are involved in the secretion of NO and TNF-alpha induced by L. donovani promastigotes
Deering et al., Clinical and vaccine immunology : CVI 2006 : Although a number of variables influence TLR ligand induced TNF responses, this assay can be optimized for potential clinical use to screen patients with primary immunodeficiencies affecting TLR function
Szczepański et al., Eur Arch Otorhinolaryngol 2006 (Cholesteatoma, Middle Ear...) : TLR-ligand binding results in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and TNF-alpha
Hu et al., Immunity 2006 (Arthritis...) : We report that IFN-gamma augments induction of TNFalpha by TLR ligands, immune complexes, and zymosan by suppressing IL-10 production and thereby interrupting Stat3 mediated feedback inhibition
Remer et al., J Immunol Methods 2006 : TLR2 , TLR4 and TLR5 agonists, but neither TLR3 nor TLR9 agonists, induced TNF production
Paul-Clark et al., Br J Pharmacol 2006 : 6. These observations are the first to clearly delineate the role of separately activating TLR2 and TLR4 in the induction of NOSII and TNFalpha genes compared with their coinduction when both receptor pathways are activated
Yadav et al., Blood 2006 : We determined that mitogen activated protein kinase ( MAPK ) activation and tumor necrosis factor-alpha (TNF-alpha) production in macrophage infected with Mycobacterium avium or M smegmatis is dependent on myeloid differentiation factor 88 ( MyD88 ) and TLR2 but not TLR4, MR, or CR3 ... Interestingly, the TLR2 mediated production of TNF-alpha by macrophages infected with M smegmatis required the beta-glucan receptor dectin-1
Levy et al., J Immunol 2006 : The adenosine system selectively inhibits TLR mediated TNF-alpha production in the human newborn ... We have previously reported that despite normal basal expression of TLRs and associated signaling intermediates, human neonatal cord blood monocytes demonstrate severe impairment in TNF-alpha production in response to triacylated ( TLR 2/1 ) and diacylated ( TLR 2/6 ) bacterial lipopeptides ( BLPs ) ... Selective inhibition of neonatal TNF-alpha production is due to the distinct neonatal adenosine system, including relatively high adenosine concentrations in neonatal blood plasma and heightened sensitivity of neonatal mononuclear cells to adenosine A3 receptor mediated accumulation of cAMP, a second messenger that inhibits TLR mediated TNF-alpha synthesis but preserves IL-6 production
Ji et al., Zhong Xi Yi Jie He Xue Bao 2006 : QGHXR can protect liver cells by down regulating the expressions of CD14, TLR(4) and NF-kappaB and inhibiting TNF-alpha expression
Mohri et al., J Trauma 2006 (Systemic Inflammatory Response Syndrome) : Expression of HO-1, TLR2 , and TLR4 in monocytes was significantly enhanced in patients with severe SIRS compared with that in healthy volunteers, whereas intracellular TNF-alpha expression with peptidoglycan was significantly decreased ( p < 0.05 ) in patients compared with that in healthy volunteers
Gao et al., Zhonghua Yan Ke Za Zhi 2006 : The activity of IkappaBalpha in THCE cells was decreased to 10.31 +/- 1.30 ( gray scale value ) and 8.15 +/- 2.37 at 30 min after challenged with AF mycelium or supernatant extract agent compared to 51.57 +/- 5.58 and 49.23 +/- 3.49 of control group ( P < 0.01 ), and was reverted at 2 h. The secretion of IL-8 and TNF-alpha was partly inhibited by blocking TLR2 or TLR4 ( P < 0.05 ), obviously inhibited by blocking TLR2 and TLR4 ( 50 % and 40 % compared to that of control group ) ( P < 0.01 ) when challenged with AF mycelium. And that was markedly inhibited by blocking TLR4 or blocking TLR2 and TLR4 when challenged with AF supernatant ( P < 0.01 ). The secretion of IL-8 and TNF-alpha was not inhibited by blocking TLR2 when challenged with AF supernatant ( P > 0.05 )
Murakami et al., Biochem Biophys Res Commun 2007 (Insulin Resistance) : These results indicate that TLR2/TNFalpha-adipocytes possibly cause the induction of TNFalpha expression in visceral fat tissues, being associated with the development of high fat induced insulin resistance
Liang et al., J Immunol 2007 (Inflammation) : LT-IIb-B ( 5 ), but not LT-IIb, induced TLR2 mediated NF-kappaB activation and TNF-alpha production
Kim et al., Immunol Lett 2007 (Arthritis, Rheumatoid...) : TLR stimulation of RA-FLS also induced the production of IL-1beta and TNF-alpha to a lesser extent ; however, it had no effect on IL-17 production
Shu et al., Clin Exp Immunol 2007 : natural killer ( NK ) 1.1 ( - ) CD11c ( + ) liver DC subsets ( conventional DCs, T cell receptor ( TcR ) beta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( - ) and plasmacytoid DCs, TcRbeta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( + ) ) efficiently endocytose dextran and produce significant levels of tumour necrosis factor (TNF)-alpha , interleukin (IL)-6 and IL-12 p40 in response to Toll-like receptor ( TLR ) ligands, with responses higher than splenic DCs
Koval'chuk et al., Zh Mikrobiol Epidemiol Immunobiol 2007 (Common Variable Immunodeficiency) : Spontaneous production of TNF-alpha by PBMC in patients with CVID was increased and accompanied by decrease in TNF-alpha production stimulated by each analyzed ligands except CpG. Observed changes in TLR dependent TNF-alpha production can play important role in pathogenesis of CVID
Yu et al., Int Immunopharmacol 2007 (Sepsis) : Ketamine 2.5, 5 and 10 mg/kg after CLP decreased intestinal TNF-alpha level and NF-kappaB activity, and inhibited TLR2 and TLR4 expressions as well
Doz et al., J Biol Chem 2007 (Inflammation) : However, we found that di-acylated LM inhibition of LPS induced tumor necrosis factor secretion by murine macrophages was independent of TLR2 , mannose receptor, or the murine ortholog SIGNR1
Barquero-Calvo et al., PloS one 2007 (Bacteremia...) : TNF-alpha-induction was TLR4- and TLR2 dependent for live but not for killed B. abortus
Sá-Nunes et al., J Immunol 2007 : Saliva at remarkably diluted concentrations ( < 1/2000 ) promotes a dose dependent inhibition of IL-12 and TNF-alpha production induced by all TLR ligands used
Ferwerda et al., J Leukoc Biol 2007 (Crohn Disease) : TLR induced TNF-alpha , IL-1beta, and IL-10 production is mediated through MyD88, whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta
Syed et al., J Neurochem 2007 : Tumor necrosis factor-alpha (TNF-alpha) regulates Toll-like receptor 2 (TLR2) expression in microglia ... In this study, we demonstrate that the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) enhances TLR2 expression in microglia, whereas interleukin-1beta has no significant effect ... To determine the downstream signaling events responsible for elevated microglial TLR2 expression in response to TNF-alpha , a series of signal transduction inhibitors were employed ... Treatment with caffeic acid phenethyl ester, an inhibitor of redox mediated nuclear factor-kappa B activation, significantly attenuated TNF-alpha induced TLR2 expression
Koval'chuk et al., Bull Exp Biol Med 2007 (Common Variable Immunodeficiency) : The production of TNF-alpha and IFN-alpha cytokines by peripheral blood mononuclears in response to stimulation by TLR2/6 , TLR4, TLR5, TLR9 ligands ( zymosan, LPS, flagellin, and CpG-oligodeoxynucleotide, respectively ) was studied in donors and patients with common variable immunodeficiency
Yu et al., Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2007 (Pneumonia...) : Ketamine at sub-anesthetic doses could suppress the production of inflammatory cytokines such as TNF-alpha and IL-6, attenuate NF-kappaB activity, and inhibit TLR2 and TLR4 expression in polymicrobial sepsis
Taneichi et al., Clin Immunol 2008 (Agammaglobulinemia...) : Stimulation with TLR2, TLR4 and TLR7/8 ligands, as well as TLR3 ligand, resulted in significantly lower production of TNF-alpha , but neither IL-6 nor IL-12p70, by DCs from XLA patients in comparison to normal controls ... Stimulation with TLR2 , TLR4 and TLR7/8 ligands, as well as TLR3 ligand, resulted in significantly lower production of TNF-alpha , but neither IL-6 nor IL-12p70, by DCs from XLA patients in comparison to normal controls
Nicol et al., J Virol 2008 (HIV Infections) : AMs from HIV positive subjects also showed decreased TNF-alpha production in response to these TLR2 and TLR4 ligands
Prescott et al., J Allergy Clin Immunol 2008 (Hypersensitivity...) : Maternal allergy ( n = 59 ) was associated with significantly higher neonatal IL-12 and IFN-gamma responses to TLR2, TLR3, and TLR4 activation, whereas TNF-alpha and IL-6 responses to TLR2 , TLR4, and TLR5 activation were significantly higher in newborns who subsequently had allergic disease ( n = 32 )
Behrens et al., J Immunol 2008 : A number of recent studies show that activation of CR3 on dendritic cells (DCs) suppresses TLR induced TNF-alpha and IL-12 production and inhibits effective Ag presentation ... TLR induced TNF-alpha and IL-12 production by bone marrow derived DCs occurs heterogeneously, with apoptotic cells inhibiting only certain populations depending on the TLR agonist
Phulwani et al., J Immunol 2008 : In addition, NF-kappaB inhibitors attenuated TNF-alpha induced TLR2 expression in astrocytes
Wikén et al., J Clin Immunol 2009 (Sarcoidosis) : Combined TLR2 and NOD2 stimulation induced a four-fold higher secretion of TNFalpha and a 13-fold higher secretion of IL-1 beta in patients
Croker et al., Proc Natl Acad Sci U S A 2008 (Autoimmune Diseases...) : TLR induced TNF and IL-1 production are normal in macrophages derived from spin mice
Sørensen et al., J Immunol 2008 (Encephalitis, Herpes Simplex) : In the brain we found that TNF-alpha and the IFN stimulated gene CXCL9 were expressed during infection and were dependent on either TLR2 or TLR9
Wu et al., Hepatology 2009 : TLR stimulated expression of proinflammatory cytokines [ tumor necrosis factor alpha (TNF-alpha) , interleukin-6 (IL-6) ], and activation of IRF-3 was suppressed after up-regulation of HBV replication in HBV-Met cells
Huang et al., Infect Immun 2009 : These two beta-glucans failed to stimulate TNF-alpha in Dectin-1 ( beta-glucan receptor ) knockout BMDCs. Costimulation of wild-type BMDCs with beta-glucans and specific Toll-like receptor ( TLR ) ligands resulted in greatly enhanced TNF-alpha production but decreased IL-12p70 production compared with TLR agonists alone
Gao et al., Inflamm Res 2009 (Myocardial Reperfusion Injury) : The present study defines the expression of Toll-like Receptor 2 (TLR2) , and the modulatory role of Glycogen synthase kinase (GSK)-3beta inhibitor on TLR2/Nuclear Factor-kappa B (NF-kappaB) signaling following myocardial ischemia-reperfusion ( MI-R ) injury in rats
Matsushita et al., Nature 2009 (Anemia...) : Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ), but not TNF , in response to TLR ligands
Chaung et al., Vet Immunol Immunopathol 2009 : Zymosan enhanced dectin-1/TLR2/TLR4 expression and TNF-alpha/IL-10 production in all of three types of cell, whereas p-beta-glucan increased dectin-1/TLR4 and TNF-alpha/IL-12 production in AMs but inhibited IL-10 in mDCs
Jung et al., Immunol Lett 2009 (Arthritis, Experimental...) : Stimulation of TLR2, TLR4 , and TLR6 by their specific ligands increased the production of TNF-alpha in FLS from IL-1Ra-deficient mice ... The aim of this study was to determine whether stimulation of toll-like receptor 2 (TLR2) , TLR4, and TLR6 by their specific ligands induces the production of tumor necrosis factor-alpha (TNF-alpha) in fibroblast-like synoviocytes ( FLS ) from interleukin-1 receptor antagonist ( IL-1Ra ) -deficient mice ... These data show that TLR2, TLR4 , and TLR6 ligation synergistically stimulates the production of TNF-alpha and IL-1beta in IL-1Ra-deficient mice and suggest that TLRs contribute to the perpetuation of spontaneous arthritis in this animal model
Covacu et al., J Immunol 2009 : TLR activation induces TNF-alpha production from adult neural stem/progenitor cells ... TLR2 expression was increased by supernatants from activated macrophages and by TNF-alpha , which synergized with IFN-gamma
Siegemund et al., J Virol 2009 : In contrast, iPPVO induced TNF-alpha release and enhanced expression of MHC-I and CD86 but not of MHC-II by BMDC chiefly requires MyD88 but not TLR2 or TLR4
Morran et al., Oral Microbiol Immunol 2009 (Diabetes Mellitus, Type 1...) : When BM-Mvarphi, obtained from diabetic NOD mice, are stimulated with P. gingivalis LPS under hyperglycemic conditions the following changes occur : reduced messenger RNA expression and cell surface expression of TLR2 , reduced messenger RNA expression and protein production of tumor necrosis factor-alpha , reduced signal transduction, and a reduction in phagocytic function
Cho et al., PloS one 2009 (Inflammation) : Utilizing this cell line, we screened a completely random lentiviral short hairpin RNA ( shRNA ) library for sequences that inhibited TLR mediated TNF-alpha production
West et al., Infect Immun 2009 (Burkholderia Infections...) : In macrophages, TLR4 and the adaptor molecule MyD88, but not TLR2 or TLR5, are required for tumor necrosis factor alpha production induced by B. thailandensis
Arancibia et al., J Cell Mol Med 2011 : Mutations of two tyrosine residues in the GR, 598 and 663, to phenylalanine significantly reduced interaction with PI3K and the GC effects on TLR2 induced TNF-a expression
Frazier et al., J Immunol 2009 (Escherichia coli Infections...) : MAPKs are crucial for TNF-alpha and IL-6 production by innate immune cells in response to TLR ligands
Wenink et al., J Immunol 2009 : The inhibitory effect of TLR2 on the release of TNF-alpha but not of IL-12p70 was mediated by PI3K
van Hoffen et al., Int Arch Allergy Immunol 2010 : Apically added LGG, TLR2 and NOD2 ligands, but not Bb, enhanced IFN-gamma, IL-12 and/or TNF-alpha secretion
Stamm et al., FEMS Immunol Med Microbiol 2010 (Vibrio Infections) : Results obtained using V. vulnificus type strain ATCC 27562 showed that ( 1 ) TLR4 signaling is myeloid differentiation factor 88 dependent and plays a key role in TNFalpha production by mouse blood and splenocytes stimulated ex vivo with inactivated V. vulnificus cells, ( 2 ) TLR4 signaling is deleterious in a mouse model of V. vulnificus infection, ( 3 ) signaling by TLR ( s ), exclusive of TLR4, is needed to eradicate infection, and ( 4 ) the TLR mediated TNFalpha response plays a critical role in determining the outcome of infection
Fang et al., FEMS Immunol Med Microbiol 2010 (West Nile Fever) : Viral antigens were detected in WNV infected gammadelta T cells.WNV infection or toll-like receptor ( TLR ) agonist treatment of gammadelta T cells induced the production of IFN-gamma, tumor necrosis factor-alpha and IL-6, which are known to promote DC maturation
Chávez-Sánchez et al., Hum Immunol 2010 : Our results suggest that mmLDL activates CD14, TLR4 , and TLR2, inducing the production of TNF-alpha and increasing the expression of TLR2 and TLR4
Mureith et al., AIDS 2010 (Disease Progression...) : Responses by THP-1 cells to TLR stimulation were quantified using Quanti-Blue colometric assay, and TLR induced tumor necrosis factor-alpha production of primary monocytes was quantified by intracellular cytokine staining using flow cytometry
Kar et al., Eur J Immunol 2011 (Inflammation...) : Analysis of upstream signaling events revealed that TLR 2/4 mediated MyD88 dependent participation of IL-1R activated kinase (IRAK)1, TNF receptor associated factor (TRAF)6 and TGFß activated kinase (TAK)1 is essential to induce cystatin mediated I?B kinase ( IKK ) /NF-?B activation in macrophages
Jiang et al., Int Immunopharmacol 2011 (Sepsis...) : Artesunate not only inhibited TNF-a and IL-6 release but also inhibited mRNA and protein expressions of TLR2 and Nod2, two important receptors, in murine peritoneal macrophages stimulated with heat killed WHO-2, further demonstrating anti-inflammatory effect of artesunate was related to the inhibition of TLR2- and Nod2 mediated proinflammatory cytokines
Caraş et al., Roum Arch Microbiol Immunol 2011 : Silencing of TLR2 led to a statistically significant inhibition of TNF-alpha secretion induced by TLR2 agonist while siRNA silencing of TLR4 did not affect the response to TLR2 agonist ... Silencing of TLR2 led to a statistically significant inhibition of TNF-a secretion induced by CANTASTIM while silencing of TLR4 had no effect on the response to CANTASTIM
Minematsu et al., Cell Signal 2011 : Treatment with VIVIT resulted in nuclear export of NFATc3/c4 and inhibited TLR activated TNF expression, suggesting that nuclear residence of NFATc is required for TLR related innate immune response
Rahman et al., J Virol 2011 (Poxviridae Infections...) : By using small interfering RNA screening, we further demonstrated that, among the RIG-I-like receptors (RLRs) and Toll-like receptors ( TLRs ), only TLR2 , TLR6, TLR7, and TLR9 contribute to the NF-?B dependent secretion of TNF and the inflammasome dependent secretion of IL-1ß in response to vMyxM013-KO virus infection
Das et al., Immunol Cell Biol 2012 (Leishmaniasis, Visceral) : In this report, we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages, leading to incapability for the production of inflammatory cytokines like tumor necrosis factor (TNF)-a and interleukin (IL)-1ß in response to TLR stimulation
Liu et al., PloS one 2011 (Inflammation) : We found that the expression of TNF-a and IL-6 induced by TLR2 engagement in uPAR-/- neutrophils was less than that in uPAR+/+ ( WT ) neutrophils
Farrar et al., FASEB J 2012 (Disease Models, Animal...) : Activation of TLR leads to activation of NF-?B and release of proinflammatory cytokines, such as IL-6 and TNF-a
Guerrero et al., Eur J Pharmacol 2012 : Moreover, the joint production of TNF-a , IL-1ß and CXCL1/KC by zymosan was dependent on TLR2/MyD88 signaling
Delpino et al., J Leukoc Biol 2012 (Brucellosis) : Macrophage elicited osteoclastogenesis in response to Brucella abortus infection requires TLR2/MyD88 dependent TNF-a production
Kim et al., J Nutr Biochem 2012 (Myocardial Infarction...) : In CMs, TLR2 and monocyte chemoattractant protein (MCP)-1 mRNAs were increased by TNF-a , PGN or H/R, whereas they were blunted by curcumin
Panda et al., J Reprod Immunol 2012 (Pre-Eclampsia) : The expression of TLR induced production of TNF-a , IFN-a, IL-6, and IL-12 were measured by multicolor flow cytometry
Zhang et al., Cell Mol Immunol 2012 : Previous studies have shown that the Toll-like receptor 2 (TLR2) is required for tumor-necrosis factor (TNF) production, whereas TLR9 is responsible for IL-12 induction in DCs after exposure to heat killed Brucella abortus ( HKBA )
Movita et al., J Leukoc Biol 2012 : Interestingly, despite expression of TLR mRNA on Kupffer cells, ligation of TLR4, TLR7/8 , and TLR9 resulted in a weak induction of IL-10, low or undetectable levels of IL-12p40 and TNF , and up-regulation of CD40 on the surface
Kawahara et al., Exp Cell Res 2012 : MMCH clones also expressed Toll-like receptors ( TLRs ) 1, 2, 4, and 6 and showed elevated levels of TNF-a expression in response to stimulation with TLR2 and TLR4 ligands
Hilda et al., FEMS Immunol Med Microbiol 2012 : Increased expression of CD32, CD64, TLR4 , and CXCR3 ; increased TNF-a secretion ; and downregulation of early apoptosis were observed in H37Rv infected neutrophils
Som et al., Clinical and vaccine immunology : CVI 2012 (Disease Models, Animal...) : Anti-inflammatory SMAMPs prevented the induction of tumor necrosis factor (TNF) , interleukin 6 (IL-6), and IL-10 in response to S. aureus or LTA, but no other TLR2 ligands
Kim et al., Microb Pathog 2013 : In addition, TLR4 was required for the optimal production of IL-6, TNF-a , and IL-12 in BMDCs in response to A. baumannii
Deng et al., Immunol Cell Biol 2013 : Further, we demonstrated that TLR induced tumor necrosis factor-a and interferon-ß contributed to the differential phagocytosis of apoptotic neutrophils and bacteria by macrophages
Negrini et al., Immunol Invest 2013 (Sporotrichosis) : The absence of TLR-2 led to lower production of the cytokines TNF-a , IL-1ß, IL-12 and IL-10 compared to WT animals
Papadopoulos et al., J Immunol 2013 (Alveolar Bone Loss...) : Whereas both TLR2 and TLR4 contributed to TNF production in naive macrophages, P. gingivalis preferentially exploited TLR2 in endotoxin-tolerant BMDM to trigger excessive TNF production ... We found that TNF induced surface TLR2 expression and augmented TLR induced cytokine production in P. gingivalis stimulated BMDM, establishing a previously unidentified TNF dependent feedback loop
Yoshida et al., J Nutr Biochem 2013 : In addition, naringenin suppresses TLR2 expression induced by the co-culture of differentiated adipocytes and macrophages and also inhibits tumor necrosis factor-a (TNF-a) induced TLR2 expression by inhibiting the activation of nuclear factor-?B and c-Jun NH2-terminal kinase pathways in differentiated adipocytes
Okan et al., mBio 2013 (Disease Models, Animal...) : In vitro stimulation of bone marrow derived macrophages with the dkdhAB mutant induced higher levels of TNF-a and IL-1ß in a TLR2 dependent manner
Karrich et al., Blood 2013 : Although IL-21 did not affect TLR induced type I IFNs, IL-6, and TNF-a nor expression of major-histocompatibility-complex class II or costimulatory molecules, IL-21 markedly increased expression of the serine protease granzyme B (GrB)
Stokes et al., Pain 2013 (Pain) : Using Tnf ( -/- ) mice, we found that IT TLR2 and TLR4 TA was tumor necrosis factor (TNF) dependent , whereas TLR3 was TNF independent
Ferrante et al., Inflammation 2013 : Adenosine signaling suppresses the TLR dependent expression of TNF-a , IL-12, IFN-?, and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10
Liu et al., Scand J Immunol 2013 : Our results demonstrate that not only TLR2 but also TLR4 and RP105 are involved in the response of macrophages to S. aureus, that TLR2, TLR4 and RP105 physically interact with each other during S. aureus infection, and that TLR2 , TLR4 and RP105 both cooperate and play unique roles in the production of inflammatory cytokines ( TNF-a , IL-12p40 and IL-10 ) and chemokine ( RANTES ) by macrophages after S. aureus infection
Liu et al., J Neurosci 2013 : In cultured neurons, TLR7 activation induced IL-6 and TNF-a expression through Myd88
Römmler et al., J Immunol 2013 : Whereas TLR9 induced TNF-a secretion of bone marrow derived macrophages and conventional dendritic cells was equally inhibited by INH-ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888, TLR7 induced TNF-a release and TLR7- and TLR9 induced IL-12p40 release were significantly more impaired by G-modified INH-ODNs