Sakatsume et al., Kidney Int 2000
(Glomerulonephritis) :
Overexpression of Stat1-mutant lacking 35 C-terminal amino acids strongly suppressed the IFN-gamma induced signal transduction and inhibited the expression of MHC class II and CIITA genes in mesangial cells
Barrionuevo et al., Clin Exp Immunol 2003
(Chronic Disease...) :
We demonstrate that IC induce a depletion not only on surface expressed but also on intracellular MHC class II content and that IC-induced down-regulation of MHC class II is not mediated by the inhibition of STAT-1 phosphorylation