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CPOX — NOS1

Text-mined interactions from Literome

Millette et al., J Hypertens 2000 (Hypertension) : The combined nitric-oxide synthase (NOS) and cyclo-oxygenase (COX) inhibition unmasked an endothelium derived hyperpolarizing factor ( EDHF ) involvement in the coronary dilation due to bradykinin in hearts from HTRs, suggesting that endothelial NO and PGI2, although unable to induce coronary smooth-muscle relaxation, can inhibit EDHF production in HTRs. Impairment in the adenylate cyclase pathway and the suppression of NO by free radicals may explain the blunted vasodilation in DOCA-salt hypertension
Czarnowska et al., Folia Histochem Cytobiol 2001 (Myocardial Reperfusion Injury) : Inhibition of NOS significantly increased apoptosis with activation of Bax protein and decrease of COX
Hurwitz et al., Reproduction 2002 : Nitric oxide ( NO ), prostaglandin E ( PGE ) and progesterone production was analysed in luteal cells of the rat corpus luteum exposed to inhibitors of non-specific NOS , inhibitors of inducible NOS (iNOS) and inhibitors of COX
Ejima et al., Antioxid Redox Signal 2004 (Endotoxemia) : The present article reviews our recent studies involving the role of cyclooxygenase (COX)-2 in host responses to bacterial endotoxemia and its role in the regulation of nitric oxide synthase (NOS)2 and heme oxygenase (HO)-1
Kawashima et al., J Dent Res 2005 (Pulpitis) : Effect of NOS inhibitor on cytokine and COX2 expression in rat pulpitis
King et al., Neurosignals 2005 (Opioid-Related Disorders...) : A non-inclusive list of examples of substances reported to block or reverse opioid antinociceptive tolerance include : substance P receptor ( NK-1 ) antagonists, calcitonin gene related peptide (CGRP) receptor antagonists, nitric oxide ( NO ) synthase inhibitors, calcium channel blockers, cyclooxygenase (COX) inhibitors , protein kinase C inhibitors, competitive and non-competitive antagonists of the NMDA ( N-methyl-D-aspartate ) receptor, AMPA ( alpha-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid ) antagonists, anti-dynorphin antiserum, and cholecystokinin (CCK) receptor antagonists
Soltow et al., Med Sci Sports Exerc 2006 (Hypertrophy) : We sought to determine whether cyclooxygenase (COX) activity is necessary for overload induced growth of adult rat skeletal muscle, and whether nitric oxide synthase (NOS) activity is involved in upregulation of COX messenger RNA ( mRNA ) expression in skeletal muscle
Kitaura et al., Neurosci Res 2007 (Hyperemia) : We perfused the surface of the cortex under the skull with 100 microM N ( G ) -nitro-l-arginine ( l-NA ), an inhibitor of NO synthase (NOS) , and 10 microM indomethacin, an inhibitor of cyclooxygenase (COX)
Stanley et al., Vascul Pharmacol 2009 (Diabetes Complications...) : Uterine arteries from term-pregnant, diabetic and control C57Bl6/J mice were assessed using acetylcholine ( ACh ; 10 ( -10 ) -10 ( -5 ) M ) in the presence or absence of a nitric oxide ( NO ) synthase inhibitor ( L-NNA ; 10 ( -5 ) M ), a cyclooxygenase (COX) inhibitor ( indomethacin ; 10 ( -5 ) M ) or the two in combination
Seyrek et al., Int Endod J 2010 : The aortic rings were then incubated with either nitric oxide synthase (NOS) inhibitor, cyclooxygenase (COX) inhibitor or K ( + ) channel inhibitors ; after pre-contraction with PE, relaxations to the various compounds of Epiphany were examined
Sojitra et al., Mol Cell Biochem 2012 (Heart Injuries) : However, co-administration of N-nitro-L-arginine methyl ester, a nitric oxide synthase (NOS) inhibitor, and Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor along with NaHS and ISO abrogated the beneficial effect of H ( 2 ) S differentially
Prati et al., Arthritis Res Ther 2012 (Arthritis, Experimental...) : The results showed that this beneficial effect is mediated by an increase in NOS activity and EDHF and reduced superoxide anion production as well as a decrease in the activity of cyclooxygenase (COX)-2 , thromboxane and prostacyclins synthases
Obermajer et al., Transplantation research 2012 : We observed that PGE2 induces endogenous cyclooxygenase (COX)2 expression in cultured monocytes, blocking their differentiation into CD1a+ dendritic cells (DCs) and inducing the expression of indoleamine 2,3-dioxygenase 1, IL-4Ra, nitric oxide synthase 2 and IL-10 - typical MDSC associated suppressive factors
Tetsuka et al., Proc Natl Acad Sci U S A 1994 : Thus we determined the effect of COX inhibition and exogenous PGs on NO production and NOS induction in rat mesangial cells
Swierkosz et al., Pol J Pharmacol 1994 : We have shown that NOS and COX are co-induced in vitro and in vivo by bacterial endotoxin and that low amounts of NO increase whereas high amounts inhibit the activity and expression of inducible COX in vitro
Dumont et al., Am J Physiol 1998 : Concordant observations were made in vitro and revealed that nNOS expression ( detected by NADPH diaphorase reactivity ) mostly present in neurons of the deeper cortical layers was reduced by COX inhibitor, and this effect was prevented by EP3 agonist