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CTNNB1 — NES
Text-mined interactions from Literome
Giannini et al., Exp Cell Res 2004
(Colonic Neoplasms) :
In addition, mutations in NES1, but not
NES2 ,
reduced binding of alpha-catenin to
beta-catenin and impaired the ability of alpha-catenin to repress beta-catenin/Tcf dependent transcription ... Therefore,
NES1 is
required both for repression of
beta-catenin signaling and for nuclear export, while NES2 is required only for nuclear export
Katayama et al., J Cell Sci 2010
:
When wt-FLIP-L is expressed in the cytoplasm by conjugation with exogenous NES ( NES-FLIP-L ), Wnt signaling is not enhanced, whereas the
NES-FLIP-L increases cytoplasmic
beta-catenin as efficiently as wt-FLIP-L. cFLIP-L physically interacts with the reporter plasmid for Wnt signaling, but not with the control plasmid