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ATG5 — TP53

Text-mined interactions from Literome

Ghavami et al., PloS one 2011 : Notably both mevalonate cascade inhibition induced autophagy and apoptosis were p53 dependent : simvastatin increased nuclear p53 accumulation, and both cyclic pifithrin-a and p53 shRNAi partially inhibited NOXA, PUMA expression and caspase-3/7 cleavage ( apoptosis ) and DRAM expression, Atg5-12 complex formation, LC3 lipidation, and autophagosome formation ( autophagy )
Gao et al., Cell Death Differ 2011 : The upregulation of ULK1 ( ULK2 ) /ATG13 complex by p53 is necessary for the sustained autophagy activity induced by DNA damage