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CCNA2 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Shen et al., Cancer Res 2008
(Neoplasms...) :
p53-p21 pathway activation was
required for the depletion of Cyclin B1,
Cyclin A , and CDC2 in Nutlin-3a treated cells and for endoreduplication after Nutlin-3a removal
Jun et al., Nat Cell Biol 2010
:
CCN1 induces DNA damage response pathways and
activates p53 and the RAC1-NOX1 complex, which generates reactive oxygen species ( ROS )
Park et al., Mol Carcinog 2012
(Colonic Neoplasms...) :
HFD feeding increased tumor tissue levels of Ki67,
cyclin A , cyclin D1, CDK2, Bcl-xL, and Bcl-2 ; reduced
p53 levels and TUNEL positive apoptotic cells ;
increased the levels of CD45, CD68, CD31, VEGF, P-VEGF receptor-2, iNOS, and COX-2 as well as hemoglobin content ; and increased the levels of HIF-1a, P-STAT3-Y705, P-STAT3-S727, P-I?B-a, P-p65, p65, P-c-Jun, P-Akt, P-ERK1/2, P-p38, and P-SAPK/JNK