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CYR61 — TP53

Text-mined interactions from Literome

Menendez et al., Oncogene 2005 (Breast Neoplasms...) : Strikingly, CYR61 overexpression impaired the accumulation of wild-type p53 following Taxol exposure, while inhibition of alphavbeta3 or ERK1/ERK2 MAPK signalings completely restored Taxol induced upregulation of p53
Lv et al., J Cell Biochem 2009 (Prostatic Neoplasms) : We further show that over-expression of dominant negative p53 or down-expression of endogenous wild-type p53 resulted in up-regulation of Cyr61 expression, suggesting a functional link between Cyr61 and p53 in cancers
Lee et al., Cancer Lett 2012 (Ovarian Neoplasms) : CYR61 controls p53 and NF-?B expression through PI3K/Akt/mTOR pathways in carboplatin induced ovarian cancer cells