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IL6 — PTX3
Text-mined interactions from Literome
Poulakis et al., Respir Med 1999
(Lung Diseases) :
The aim of this study was to investigate the
effects of
pentoxifylline ( PTX ) on the production of TNF-alpha, IL-1 beta,
IL-6 and GM-CSF by lipopolysaccharide (LPS) stimulated alveolar macrophages ( AM )
Guo et al., Eur J Endocrinol 2000
(Bone Resorption...) :
( 1 )
PTX decreases bone resorption immediately and ( 2 ) circulating
IL-6 is not
involved in the changes in bone turnover immediately after PTX
Marcinkiewicz et al., Immunopharmacology 2000
:
PTX also
affects the production of other cytokines such as IL-1,
IL-6 , IL-10, IL-12, and IFN-gamma
Hoebe et al., Biochem Pharmacol 2001
:
PTX completely inhibited LPS induced TNF-alpha production and
attenuated IL-6 only after 48 hr of incubation
Klouche et al., AIDS 2002
(Acute-Phase Reaction...) :
Human herpesvirus 8-derived viral
IL-6 induces
PTX3 expression in Kaposi 's sarcoma cells
Schandené et al., Immunology 1992
:
In this study, we found that
PTX differentially
regulates the production of TNF-alpha and
interleukin-6 (IL-6) ... Indeed,
PTX at high concentrations
triggers the production of
IL-6 but not of TNF-alpha by peripheral blood mononuclear cells ( PBMC ) ... Further experiments indicated that monocytes are responsible for this
PTX induced
IL-6 production ... In this system,
PTX was found to
inhibit the secretion of both TNF-alpha and
IL-6 by T cells ... We suggest that cAMP could be involved in these differential
effects of
PTX on production of TNF-alpha and of
IL-6
Banfi et al., J Pharmacol Exp Ther 2004
(Brain Ischemia...) :
PTX treatment did
induce a greater increase of serum tumor necrosis factor-alpha (TNF-alpha), but not of interleukin (IL)-1beta and
IL-6 induced by in vivo administration of lipopolysaccharide (LPS), which suggests a protective role for TNF-alpha
Ji et al., Ann Clin Lab Sci 2004
(Disease Models, Animal...) :
At all dosages,
PTX reduced the activation of NF-kappaB and the production of TNF-alpha and
IL-6 , but enhanced the release of IL-10 ... In conclusion,
PTX suppressed the production of proinflammatory cytokines such as TNF-alpha and
IL-6 in rat intestine, and enhanced the endotoxin induced production of IL-10
Volman et al., Intensive Care Med 2005
(Multiple Organ Failure) :
Although
PTX inhibited the lipopolysaccharide induced increase in tumor necrosis factor alpha and
interleukin 6 expression ( but not interleukin 1beta expression ) at both mRNA and protein level in a murine macrophage cell line, tumor necrosis factor alpha mRNA expression in the livers of PTX treated mice was not significantly inhibited
Rizzi et al., J Immunol 2006
:
In these cells,
PTX-B neither
down-regulated the
IL-6R nor prevented IL-6 induced signaling in terms of STAT3 phosphorylation and DNA binding
Tian et al., Proc Natl Acad Sci U S A 2006
(Reperfusion Injury) :
The superior effects of
PTX are
mediated by
IL-6
Schneider et al., Infect Immun 2007
:
Stimulation of T cells with holotoxin (
PTx ) or the B subunit alone ( PTxB ) rapidly
induces signaling events resulting in inositol phosphate accumulation, Ca ( 2+ ) mobilization,
interleukin-2 (IL-2) production, and mitogenic cell growth
Yosef-Levi et al., Harefuah 2007
(Cardiovascular Diseases) :
CRP is a
pentraxin regulated mainly by
IL-6
Zhao et al., Biochem Biophys Res Commun 2008
(Encephalomyelitis, Autoimmune, Experimental...) :
Moreover, icv
PTx induced Th17 infiltration and increased expression of cytokines
IL-6 and TGF-beta
Spach et al., J Immunol 2009
(Encephalomyelitis, Autoimmune, Experimental...) :
However, only RANTES,
IL-6 , and IFN-gamma
increased significantly with both genetic compensation and
PTX treatment
Szajnik et al., Oncogene 2009
(Carcinoma...) :
In MyD88 ( + ) SCOV3 cells, LPS or
PTX binding to TLR4 induced IRAK4 activation and cJun phosphorylation, activated the NF-kappaB pathway and
promoted interleukin (IL)-8,
IL-6 , vascular endothelial growth factor and monocyte chemotactic protein-1 production and resistance to drug induced apoptosis
Richard et al., Brain Pathol 2011
(Encephalomyelitis, Autoimmune, Experimental) :
In a series of experiments using DNA microarrays, knockout mice and neutralizing antibodies, we found that
PTX acts indirectly on the endothelium in part through
IL6 , which is essential for the post-transcriptional upregulation of intercellular adhesion molecule 1 ( ICAM1 ) in response to PTX but not to LPS
Roy et al., Journal of neuroinflammation 2012
(Disease Models, Animal...) :
IL-6 upregulated CXCL1 expression in brain endothelial cells by acting transcriptionally and
mediated the stimulatory effect of
PTX on CXCL1 expression
Yamamoto et al., Hemodial Int 2013
(Cardiovascular Diseases...) :
While C-reactive protein did not change,
interleukin-6 (IL-6) increased by 14 % and
pentraxin 3 (PTX3) increased by 45 %
Yang et al., Int J Nanomedicine 2013
:
In addition, the
PTX-NPs markedly
inhibited interleukin-6 secretion, increased caspase-8, caspase-9, and caspase-3 expression, and induced apoptosis of tumor cells in the treated mice
Neuner et al., Immunology 1994
:
Due to the therapeutic implications, the present study addressed the in vivo
effects of
PTX on the release of TNF-alpha, IL-1 beta,
IL-6 and IL-8 by human peripheral blood mononuclear cells ( PBMC )
Bernard et al., J Cardiovasc Pharmacol 1995
:
Because inflammatory processes involve both leukocytes and vascular cells, we tested the
effects of
PTX on TNF and
interleukin-6 (IL-6) production by the vessel wall in response to lipopolysaccharide (LPS)
Okuda et al., Immunopharmacology 1996
(Encephalomyelitis, Autoimmune, Experimental) :
Semiquantitative reverse transcriptase-polymerase chain reaction analysis revealed that
PTX at this dose
reduced the mRNA levels for tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and
IL-6 in peripheral blood mononuclear cells ( PBMC ) of mice with EAE
Tsang et al., ASAIO J 1996
(Albuminuria) :
A double blind, prospective, randomized, placebo controlled, parallel study was undertaken to assess the
effect of
PTX on leukotriene B4, complement fragment C3a,
interleukin 6 (IL6), endothelial injury as measured by von Willebrand factor (vWf), and endothelial permeability as measured by urinary albumin excretion ( expressed as excreted urinary albumin to creatinine ratio [ ACR ] ) in patients undergoing cardiopulmonary bypass ( CPB ) for elective coronary artery bypass grafting
Dong et al., J Clin Immunol 1997
:
PTX at a 3.5 x 10 ( -5 ) M concentration significantly
inhibited T cell proliferation and the production of tumor necrosis factor-alpha,
interleukin-2 , and interleukin-4
D'Hellencourt et al., Int J Immunopharmacol 1996
:
We investigated
PTX effects on production and mRNA expression of TNF alpha, IL-1 beta,
IL-6 , IL-8, TNF beta and IL-10 ... We also noted that the
effects of
PTX on
IL-6 , IL-8 and IL-10 production were different in WB and in PBMC culture
Schratzberger et al., Immunopharmacology 1999
:
In the present study, we investigated the
effects of the anti-inflammatory drug
pentoxifylline ( PTX ) on activation of endothelial cells for enhanced adhesion and transmigration of neutrophils by lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF),
interleukin-1 (IL-1) and granulocyte colony stimulating factor ( G-CSF )