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BMP2 — ESR1

Text-mined interactions from Literome

Zhou et al., Mol Endocrinol 2003 : To investigate if estrogens increase BMP-2 expression by transcriptional mechanisms and if the response is mediated by ERalpha and/or ERbeta, we studied the effects of estrogens on BMP-2 promoter activity in transient transfected C3H10T1/2 cells ... At a dose of 10 nM E2, ERalpha induced mouse BMP-2 promoter activity 9-fold, whereas a 3-fold increase was observed in cells cotransfected with ERbeta ... Our studies demonstrate that E2 activation of mouse BMP-2 gene transcription requires ERalpha or ERbeta acting via a variant estrogen-responsive element binding site in the promoter, with ERalpha being the more efficacious regulator
Su et al., J Biol Chem 2007 (Breast Neoplasms...) : The bone-protective effect was attributable to induction of bone morphogenetic protein-2 through Src kinase dependent estrogen receptor activation and FOXA1 is required for resveratrol induced estrogen receptor dependent bone morphogenetic protein-2 expression
Otani et al., J Endocrinol 2009 : Expression levels of Eralpha and Erbeta were reduced by BMP2 and BMP4, but were increased by BMP6 and BMP7
Almeida et al., J Bone Miner Res 2010 : The inhibitory effect of the hormone on BMP-2 signaling resulted from an ERalpha mediated activation of ERKs and the phosphorylation of Smad1 at the linker region of the protein, which leads to proteasomal degradation