Gene interactions and pathways from curated databases and text-mining

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CCR6 — IFNG

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: CCR6 → IFNG (increases)
    Evidence: CCR6 is expressed by airway epithelial cells in response to IFNG.

Text-mined interactions from Literome

Dieu-Nosjean et al., J Immunol 2001 : IL-10 induces CCR6 expression during Langerhans cell development while IL-4 and IFN-gamma suppress it ... In contrast, IFN-gamma induced CCR6 loss was irreversible and was concomitant to the induction of DC maturation
Facco et al., J Leukoc Biol 2007 (Acute Disease...) : In vitro kinetic studies demonstrated that CCR6 is induced rapidly by IL-2, IL-18, and IFN-gamma
Rivino et al., J Exp Med 2010 : However, optimal TCR stimulation of CCR6 ( + ) T cells induced expression of IL-2, interferon-gamma , CCL20, and CD40L, and autoreactive CCR6 ( + ) T cell lines responded to various recall antigens
Zella et al., Blood 1998 : Interferon-gamma increases expression of chemokine receptors CCR1, CCR3 , and CCR5, but not CXCR4 in monocytoid U937 cells