Gene interactions and pathways from curated databases and text-mining

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HDAC2 — IFNG

Text-mined interactions from Literome

Mishra et al., Proc Natl Acad Sci U S A 2001 (Lupus Erythematosus, Systemic) : Here, we demonstrate that the histone deacetylase inhibitor, trichostatin A, significantly down-regulated CD154 and IL-10 and up-regulated IFN-gamma gene expression in SLE T cells
Osborne et al., Mol Cell Biol 2001 : These findings represent the first evidence that HDAC activity can repress IFN-gamma-inducible HLA class II gene expression and also demonstrate that HDAC activity can contribute to promoter repression following the establishment of a DNase I-hypersensitive chromatin conformation
Zika et al., Mol Cell Biol 2003 : The results show that an inhibitor of HDACs, trichostatin A, enhances IFN-gamma induced MHC-II expression, while HDAC1/HDAC2 inhibits IFN-gamma- and CIITA induced MHC-II gene expression
Guo et al., Mol Cells 2006 : Our data indicate that IFNgamma and STAT dependent gene transcription requires the participation of HDAC , as does the IFNalpha-STAT pathway
Keslacy et al., Mol Pharmacol 2007 (Inflammation) : It is noteworthy that IFNgamma decreases TNFalpha induced histone acetyl transferase ( HAT ) and increases histone deacetylase (HDAC) activities
Choi et al., J Immunol 2009 : Importantly, histone deacetylase (HDAC) inhibitors significantly enhanced IFN-gamma-inducible gene expression in trophoblast cells, but not fibroblasts ... Importantly, histone deacetylase (HDAC) inhibitors significantly enhanced IFN-gamma-inducible gene expression in trophoblast cells, but not fibroblasts ... We propose that HDAC mediated inhibition of IFN-gamma-inducible gene expression in mouse trophoblast cells may contribute to successful pregnancy by preventing activation of IFN-gamma responses that might otherwise facilitate the destruction of the placenta
Brown et al., J Interferon Cytokine Res 1997 : The NRD ( NF-kappa B/Rel/Dorsal ) complexes induced by LPS and IFN-gamma were further characterized by addition of antisera to electrophoretic mobility shift assay ( EMSA ) reaction mixtures