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RAC1 — RPS6KB1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Bae et al., Exp Cell Res 2004
:
Hydrogen peroxide mediates
Rac1 activation of
S6K1 ... In this study, we investigated a possible role of H2O2 as a molecular linker in
Rac1 activation of
S6K1 ... Similarly, PDGF activation of S6K1 was significantly inhibited by transient transfection or stable transfection of the cells with a dominant negative Rac1 ( Rac1N17 ), while overexpression of constitutively active
Rac1 ( Rac1V12 ) in the cells
led to an increase in basal activity of
S6K1 ... More importantly, elimination of H2O2 produced in Rat2 cells overexpressing Rac1V12 inhibited the Rac1V12 activation of S6K1, indicating the possible role of H2O2 as a mediator in the
activation of
S6K1 by
Rac1 ... Taken together, these results suggest that H2O2 plays a pivotal role as a mediator in
Rac1 activation of
S6K1
Liu et al., J Biol Chem 2010
:
Ectopic expression of rapamycin-resistant and constitutively active
S6K1 partially
prevented rapamycin inhibition of RhoA,
Rac1 , and Cdc42 expression, whereas expression of constitutively hypophosphorylated 4E-BP1 ( 4EBP1-5A ) or down-regulation of S6K1 by RNA interference suppressed expression of the GTPases, suggesting that both mTORC1 mediated S6K1 and 4E-BP1 pathways are involved in protein synthesis of the GTPases