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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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IRS1 — JUN

Text-mined interactions from Literome

Svegliati-Baroni et al., Am J Pathol 2006 (Disease Models, Animal...) : HFD also decreased adiponectin mRNA and peroxisome proliferator activated receptor ( PPAR)-alpha expression in the visceral adipose tissue and the liver, respectively, and induced hepatic insulin resistance through TNF-alpha mediated c-Jun N-terminal kinase (JNK) dependent insulin receptor substrate-1Ser307 phosphorylation
Ma et al., J Neurosci 2009 (Alzheimer Disease...) : Here, we investigate the role of Abeta oligomer induced c-Jun N-terminal kinase (JNK) activation leading to phosphorylation and degradation of the adaptor protein insulin receptor substrate-1 (IRS-1)
Yoneyama et al., Mol Cell Biol 2013 : These data demonstrate the importance of AP-1 dependent localization of IRS-1 in mediating IGF-I stimulated signaling and maximum mitogenic response
Jia et al., Mol Cell Biochem 2013 (Alzheimer Disease...) : TNF-a/c-Jun N-terminal kinase (JNK) signaling plays a central role in serine phosphorylation of insulin receptor substrate-1 (IRS-1)