Gene interactions and pathways from curated databases and text-mining

◀ Back to IGF1R

AR — IGF1R

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: AR → IGF1R (increases, IGF1R Activity, AR Activity)
    Evidence: Insulin-like growth factor-I (IGF-I), at a concentration of 50 ng/ml, stimulated AR-mediated reporter gene transcription to the same extent as the synthetic androgen methyltrienolone.

Text-mined interactions from Literome

Schayek et al., Clin Cancer Res 2009 (Prostatic Neoplasms) : Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor ( IGF-IR ) gene transcription in an androgen receptor dependent manner
Schayek et al., Mol Cell Endocrinol 2010 (Prostatic Neoplasms) : Differential regulation of insulin-like growth factor-I receptor gene expression by wild type and mutant androgen receptor in prostate cancer cells