Gene interactions and pathways from curated databases and text-mining

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CDK4 — IL6

Text-mined interactions from Literome

Mori et al., Biochem Biophys Res Commun 1999 (Prostatic Neoplasms) : Interleukin-6 induces G1 arrest through induction of p27 ( Kip1 ), a cyclin dependent kinase inhibitor, and neuron-like morphology in LNCaP prostate tumor cells
Urashima et al., Leukemia 1997 (Multiple Myeloma) : In these cells, IL-6 triggered a sustained increase in CDK4 by day 1 and a gradual increase in p16 to day 9