Lee et al., Invest Ophthalmol Vis Sci 2012
:
Use of specific inhibitor to PI 3-kinase or IRAK demonstrated that IRAK activates PI 3-kinase , the signaling of which phosphorylates IKKa/ß and degrades I?B, subsequently leading to activation of NF-?B
Bavelloni et al., J Cell Sci 1999
(Osteosarcoma) :
Recent evidence indicates that phosphatidylinositol 3-kinase ( PI3-kinase ) could be activated by a direct association with the activated IL-1 receptor