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NOS2 — RHOA

Text-mined interactions from Literome

Kreiselmeier et al., Am J Physiol Lung Cell Mol Physiol 2003 (Adenocarcinoma, Bronchiolo-Alveolar...) : Previous evidence also suggests that NOS2 expression can be negatively regulated by increased activation of the GTPase RhoA , leading to the hypothesis that CF-related increases in PIAS1 expression and altered STAT1 signaling may be mediated by Rho GTPase function
Rattan et al., Free Radic Biol Med 2003 : Rho A negatively regulates cytokine mediated inducible nitric oxide synthase expression in brain derived transformed cell lines : negative regulation of IKKalpha ... Taken together, these studies show that downregulation of RhoA by lovastatin resulted in increased iNOS expression via the activation of NF-kappaB-CBP/p300 pathway in transformed brain cells
Bivalacqua et al., Proc Natl Acad Sci U S A 2004 (Body Weight...) : RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis : a mechanism for diabetes associated erectile dysfunction
Liao et al., J Investig Med 2004 (Cardiomegaly...) : Furthermore, inhibition of RhoA by statins leads to the activation of protein kinase B/Akt and up-regulation of endothelial nitric oxide synthase in the endothelium and the heart
Mital et al., Semin Vasc Med 2004 (Cardiomegaly) : Furthermore, inhibition of RhoA by statins leads to the activation of protein kinase B/Akt and upregulation of Type 3 nitric oxide synthase in the endothelium and the heart
Trebicka et al., Hepatology 2007 (Liver Cirrhosis) : Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase
Soliman et al., Cardiovasc Res 2008 (Diabetes Mellitus, Experimental...) : Role of inducible nitric oxide synthase in induction of RhoA expression in hearts from diabetic rats ... Therefore, in this study, we investigated the hypothesis that induction of iNOS positively regulates RhoA expression in diabetic rat hearts ... To determine whether NO and iNOS could increase RhoA expression in the heart, cardiomyocytes from non-diabetic rats were cultured in the presence of the NO donor sodium nitroprusside ( SNP ) or lipopolysaccharide (LPS) in the absence and presence of the selective iNOS inhibitor, N ( 6 ) - ( 1-iminoethyl ) -l-lysine dihydrochloride ( L-NIL ) ... In a second study, 1 week after induction of diabetes with STZ, rats were treated with L-NIL ( 3 mg/kg/day ) for 8 more weeks to determine the effect of iNOS inhibition in vivo on RhoA expression and cardiac contractile function ... These data suggest that iNOS is involved in the increased expression of RhoA in diabetic hearts and that one of the mechanisms by which iNOS inhibition improves cardiac function is by preventing the upregulation of RhoA and its availability for activation
Soliman et al., Am J Physiol Heart Circ Physiol 2012 (Diabetes Mellitus, Experimental...) : Inhibition of RhoA and ROCK markedly attenuated the diabetes induced increases in PKCß ( 2 ) activity and iNOS and RhoA expression in diabetic cardiomyocytes, while having no effect in control cells
Tong et al., Inflammation 2013 : Taken together, our findings suggest that iNOS mediated activation of RhoA appears to be one of the important mechanisms contributing to the deleterious effects of alcohol on intestinal barrier function