Gene interactions and pathways from curated databases and text-mining

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PAK7 — RELA

Text-mined interactions from Literome

Tseng et al., Am J Physiol Cell Physiol 2006 (Inflammation) : Apical Pseudomonas aeruginosa strain PAK ( but not flagellin mutant PAK.fliC ), flagellin, and flagellin + PAK.fliC activated NF-kappaB and IL-8 expression and secretion
Orr et al., Circ Res 2008 : We now show that inhibiting PAK in cells on fibronectin blocked NF-kappaB activation by both laminar and oscillatory flow in vitro and at sites of disturbed flow in vivo ... These data demonstrate that PAK controls NF-kappaB activation by modulating the sensitivity of cells to ROS