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PTPN11 — SIRPA
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
PTPN11
→
SIRPA
(reaction)
-
Reactome Reaction:
PTPN11
→
SIRPA
(indirect_complex)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Oh et al., Mol Cell Biol 1999
:
Overexpression of
SHPS-1 in 293 cells potentiated integrin induced mitogen activated protein kinase ( MAPK ) activation, and potentiation
required functional
SHP-2
Wu et al., Oncogene 2000
(Brain Neoplasms...) :
SIRPalpha1 overexpression also
reduced the EGF induced association between
SHP2 and the p85 regulatory subunit of PI3-K
Araki et al., J Neurochem 2000
:
Overexpression of wild-type
BIT/SHPS-1 , but not the 4F mutant, in cultured cerebral cortical neurons
induced tyrosine phosphorylation of BIT/SHPS-1 itself and an association of
Shp-2 with BIT/SHPS-1 even without addition of BDNF
Maile et al., Mol Biol Cell 2003
:
Disruption of
IAP-SHPS-1 binding, by using an IAP monoclonal antibody or cells expressing mutant forms of IAP that did not bind to SHPS-1,
inhibited IGF-I stimulated SHPS-1 phosphorylation and
SHP-2 recruitment
Chen et al., Cancer Res 2004
(Astrocytoma...) :
Moreover, SIRPalpha1 in each of the two cell lines recruited
SHP-2 on phosphorylation, and
SIRPalpha1 phosphorylation in cultured cells is CD47
dependent
Ogura et al., J Biol Chem 2004
(Melanoma, Experimental...) :
The adhesion receptor
SHPS-1 activates the protein-tyrosine-phosphatase
SHP-2 and thereby promotes integrin mediated reorganization of the cytoskeleton
Mitsuhashi et al., J Neurochem 2008
:
Various neurotrophic factors
induce the tyrosine phosphorylation of SHPS-1 and the association of
SHPS-1 with the protein tyrosine phosphatase
SHP-2
Tsuda et al., J Biol Chem 1998
:
These results indicate that the binding of integrins to the extracellular matrix induces tyrosine phosphorylation of SHPS-1 and its association with
SHP-2 , and that such phosphorylation of
SHPS-1 requires both focal adhesion kinase and an Src family kinase