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PTPN11 — SOCS3

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SOCS3 — PTPN11 (direct interaction, pull down) Lehmann et al., J Biol Chem 2003*
• IRef Biogrid Interaction: SOCS3 — PTPN11 (physical association, affinity chromatography technology) Orr et al., J Biol Chem 2007*
• IRef Biogrid Interaction: SOCS3 — PTPN11 (physical association, affinity chromatography technology) Schmitz et al., J Biol Chem 2000
• IRef Biogrid Interaction: SOCS3 — PTPN11 (physical association, affinity chromatography technology) Lehmann et al., J Biol Chem 2003*
• MIPS CORUM LMO4-gp130 complex: LMO4-gp130 complex complex (IL6ST-JAK1-LMO4-PTPN11-SOCS3) Novotny-Diermayr et al., J Biol Chem 2005
• IRef Corum Interaction: Complex of SOCS3-JAK1-IL6ST-LMO4-PTPN11 (association, anti tag coimmunoprecipitation) Novotny-Diermayr et al., J Biol Chem 2005
• IRef Hprd Interaction: SOCS3 — PTPN11 (in vitro) Lehmann et al., J Biol Chem 2003*

Text-mined interactions from Literome

Schmitz et al., J Biol Chem 2000 : The activation of one inhibitor modulates the activity of the other ; Inhibition of SHP2 activation leads to increased SOCS3-mRNA levels, whereas increased expression of SOCS3 results in a reduction of SHP2 phosphorylation after activation of the interleukin-6 signal transduction pathway
Bjorbak et al., J Biol Chem 2000 : Additionally, overexpression of SOCS3 , but not SHP-2, impairs ELR signaling, and the overexpression of SHP-2 blunts SOCS3 mediated inhibition of ELR signaling