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IL17A — TRAF6

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TRAF6 — IL17A (physical association, affinity chromatography technology) Liu et al., Science signaling 2009*

Text-mined interactions from Literome

Chang et al., J Biol Chem 2006 (Inflammation...) : An earlier study found that IL-17 activates NF-kappaB and MAPK pathways and requires TRAF6 to induce IL-6
Rong et al., Cell Signal 2007 : Our results indicate that ubiquitination of IL-17R mediated by TRAF6 plays a critical role in IL-17F signaling
Chang et al., Cell Res 2007 (Inflammation) : IL-17A/F regulation of IL-6 and KC expression is dependent on IL-17RA and TRAF6
Huang et al., J Immunol 2007 : Requirement for both JAK mediated PI3K signaling and ACT1/TRAF6/TAK1 dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells
Hartupee et al., J Immunol 2009 : IL-17 signaling for mRNA stabilization does not require TNF receptor associated factor 6
Hot et al., Ann Rheum Dis 2011 (Arthritis, Rheumatoid) : IL-17A and, to a lesser extent, IL-17F induced TRAF6 but not MyD88
Garg et al., Science signaling 2013 : A20 associated with the E3 ubiquitin ligase TRAF6 ( tumor necrosis factor receptor associated factor 6 ) in an IL-17 dependent manner and restricted the IL-17 dependent activation of NF-?B and mitogen activated protein kinases