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Paris et al., Apoptosis 2007
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A cathepsin B/L inhibitor partially suppresses caspase activation and apoptosis induction, indicating signaling between lysosomes and mitochondria
Baumgartner et al., Am J Physiol Gastrointest Liver Physiol 2007
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In contrast, caspase-8 but not caspase-9 activation was blocked by the destruction of lysosomes ( preincubation with Gly-Phe beta-naphthylamide, a cathepsin C substrate ), loss of lysosomal acidity ( bafilomycin A1 ), or inhibition of cathepsin L or D. Using pepstatin A-BODIPY FL conjugate, we confirmed translocation of cathepsin D out of lysosomes in response to menadione