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IRF6 — SPHK1

Text-mined interactions from Literome

Ding et al., Prostaglandins Other Lipid Mediat 2010 (Sepsis) : Bacterial LPS increases the activity of sphingosine kinase 1 (SK1) , which catalyzes formation of sphingosine-1-phosphate ( S1P )
Gurgui et al., Cell Signal 2010 : Although our experimental data clearly show the mediatory role of sphingosine kinase ( SK ) -derived S1P in the TNF-alpha and the LPS induced activation of NF-kB, exogenously added S1P failed to trigger this transcription factor
Lin et al., Journal of neuroinflammation 2011 (Anoxia) : SphK1 immunofluorescence expression, which appeared to be weak in AMC in normal brain, was markedly induced by lipopolysaccharide (LPS) or hypoxia treatment
Fischer et al., PloS one 2011 (Inflammation...) : Activation of SphK by LPS stimulation was confirmed by SphK activity assay and was blocked by the use of the SphK inhibitor SKI ( 2- ( p-hydroxyanilino ) -4- ( p-chlorphenyl ) thiazole
Grin'kina et al., PloS one 2012 (Central Nervous System Diseases...) : These results suggest that SphK1 activation is involved in the regulation of LPS induced brain injury