Race et al., J Neurochem 1985
(Pheochromocytoma) :
Published experiments both support and contradict the hypothesis that nerve growth factor (NGF) can regulate adenylate cyclase activity
Ortego et al., J Neurochem 1997
:
Using a human cell line, ODM-2, derived from the nonpigmented ciliary epithelium, we demonstrate that ( 1 ) NT expression is highly activated by nerve growth factor , glucocorticoid, and activators of adenylate cyclase; (2) NTr expression is up-regulated by selective ligand activated beta2-adrenergic receptor ; and ( 3 ) PC1 and PC2 expression are up-regulated via distinct signaling transduction pathways