◀ Back to NGF

HCLS1 — NGF

Text-mined interactions from Literome

Harrison et al., J Comp Neurol 2000 : Levels of nerve growth factor and neurotrophin-3 are affected differentially by the presence of p75 in sympathetic neurons in vivo
Ping et al., J Neurosci Res 2002 : Considering the evidence for the role of p75 ( NTR ) in regulating survival, growth and nerve growth factor responsiveness of cholinergic basal forebrain neurons, the results indicate an important aspect of estrogen 's effects on the nervous system
Nykjaer et al., Nature 2004 : Thus sortilin acts as a co-receptor and molecular switch governing the p75NTR mediated pro-apoptotic signal induced by proNGF
Murray et al., J Neurosci 2004 : A novel p75 neurotrophin receptor related protein, NRH2, regulates nerve growth factor binding to the TrkA receptor
Turner et al., J Neurosci Res 2004 (Amyotrophic Lateral Sclerosis...) : To test the role of NGF dependent p75 ( NTR ) -mediated signalling in ALS, we examined the effects of a cyclic decapeptide antagonist of p75 ( NTR ) ligand binding by using neurotrophin stimulated cell death assays and transgenic ALS mice
Blöchl et al., Eur J Neurosci 2004 : Stimulation of p75 with nerve growth factor causes Ras activation via adapter proteins known from Trk signalling and induces rapid outgrowth of cellular processes
Longo et al., CNS Neurol Disord Drug Targets 2008 (Neurodegenerative Diseases) : Ligand independent and/or proNGF induced p75 ( NTR ) signaling has emerged as a potential major contributor to a number of pathological states, including axotomy induced death, motor neuron degeneration, neuronal degeneration in Alzheimer 's disease and oligodendrocyte death following spinal cord injury
Zhang et al., J Physiol 2008 : Previously, we demonstrated that nerve growth factor (NGF) increased the excitability of sensory neurons through activation of p75 ( NTR ) to liberate sphingosine 1-phosphate
Covaceuszach et al., Biochem Biophys Res Commun 2010 (Hereditary Sensory and Autonomic Neuropathies...) : Nerve Growth Factor (NGF) signalling is mediated by the TrkA and p75NTR receptors
Fortress et al., Journal of aging research 2011 : The data suggest that the increase in p75NTR with AD may be mediated by elevated pro-NGF levels as a result of decreased cleavage, and that pro-NGF may be partially responsible for age related degenerative changes observed in the basal forebrain
Siao et al., J Exp Med 2012 (Myocardial Infarction...) : We describe induction of proNGF by cardiomyocytes, and p75 ( NTR ) in human arterioles after fatal myocardial infarction, but not with unrelated pathologies ... After mouse cardiac ischemia-reperfusion ( I-R ) injury, rapid up-regulation of proNGF by cardiomyocytes and p75 ( NTR ) by microvascular pericytes is observed
Guo et al., Stem cell research 2013 : proNGF decreased the phosphorylation level of extracellular signal responsive kinase 1/2 ( ERK 1/2 ) in a p75NTR dependent manner under both self-renewal and differentiation conditions
Nataf et al., J Neurosci Res 1998 (Encephalomyelitis, Autoimmune, Experimental) : Recent studies have shown that nerve growth factor (NGF) can act also on immune cells through its binding to p75
Bilderback et al., J Biol Chem 1999 : Furthermore, the in vivo kinetics of the inhibition of Trk A tyrosine kinase activity by caveolin expression correlated with an increased ability of NGF to induce sphingomyelin hydrolysis through p75 ( NTR )