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IL6 — ITIH4

Text-mined interactions from Literome

Ledeboer et al., Pain 2005 (Hyperesthesia...) : In contrast, no significant effects of minocycline were observed on gp120 induced IL-6 and cyclooxygenase-2 expression in spinal cord or CSF IL-6 levels
Harraghy et al., Clin Diagn Lab Immunol 2005 : However, IL-1beta was shown to inhibit the IL-6 induced activation of the porcine ITIH4 promoter
Wieseler-Frank et al., Brain Behav Immun 2007 (Pain) : These studies demonstrate that : ( a ) intrathecal gp120 upregulates meningeal gene expression of proinflammatory signals, including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin 6 (IL-6), and inducible nitric oxide synthase (iNOS), and ( b ) intrathecal gp120 induces meningeal release of TNF-alpha, IL-1beta, and IL-6
Yang et al., Microvasc Res 2009 (AIDS Dementia Complex) : The STAT1 inhibitor, fludarabine, prevented gp120 induced IL-6 and IL-8 secretion
Shah et al., PloS one 2011 : HIV-1 gp120 induces expression of IL-6 through a nuclear factor-kappa B-dependent mechanism : suppression by gp120 specific small interfering RNA ... Transfection of a human astrocyte cell line with a plasmid encoding gp120 resulted in increased expression of IL-6 at the levels of mRNA and protein by 51.3±2.1 and 11.6±2.2 fold respectively ; this effect of gp120 on IL-6 expression was also demonstrated using primary human fetal astrocytes ... These results demonstrate that HIV-1 gp120 mediated over-expression of IL-6 in astrocytes is one mechanism responsible for neuroinflammation in HIV infected individuals and this is mediated by the NF-?B pathway
Chung et al., J Immunol 2012 : Specifically, gp120 inhibited the CpG induced maturation of pDCs and their expression of TNF-a, IL-6 , TLR9, IFN regulatory factor 7, and BAFF
Shah et al., PloS one 2012 (MAP Kinase Signaling System) : Our results clearly suggest that gp120 and MA affect IL-6 but not IL-8 in a synergistic manner and this synergy was mediated by PI3K/Akt and NF-?B pathways
Molina et al., J Virol 1990 : Our studies indicate that, in the absence of endotoxin, HIV-1, HIV-2, and HIV gp120 do not induce production of IL-1 beta, IL-6 , or TNF-alpha by peripheral blood mononuclear cells
Li et al., J Biol Chem 2013 (MAP Kinase Signaling System) : We show that inhibition of Wnt5a by specific antagonists blocks gp120 induced up-regulation of IL-1ß, IL-6 , and TNF-a in the spinal cord
Zembala et al., Clin Immunol Immunopathol 1995 : Unexpectedly, FL gp120 but not rp120cd stimulated IL-6 secretion and IL-6 mRNA synthesis in monocytes ... The FL gp120 induced production of IL-6 by monocytes was inhibited by anti-CD4 monoclonal antibody ( MAb )
Kong et al., Cell Immunol 1996 (Inflammation) : Since nitric oxide ( NO ) and proinflammatory cytokines ( TNF-alpha, IL-1, IL-6 ) produced by glial cells have been involved in the neuropathogenesis of various diseases, this study examined the effects of gp120 obtained from two strains, HIV-1IIIB and HIV-1SF2, of the HIV-1 virus on the production of NO, TNF-alpha, IL-1 alpha, IL-1 beta, and IL-6 in murine primary mixed glial cell cultures ... To investigate the cellular sources and mechanisms of the gp120 induced IL-6 production, in situ hybridization with mRNA for IL-6 was performed in HIV-1IIIB gp120- or HIV-1SF2 gp120 stimulated microgliaenriched or astrocyte enriched cultures ... HIV-1IIIB gp120 or HIV-1SF2 gp120 induced the expression of IL-6 mRNA in both microglia enriched and astrocyte enriched cultures, indicating that both microglia and astrocytes produce IL-6, and that the transcriptional regulation is involved in the gp120 induced IL-6 production ... Taken together, these results demonstrate that the production of NO, TNF-alpha, IL-1, or IL-6 from glial cells is differentially regulated by HIV-1IIIB gp120 and HIV-1SF2 gp120
Eddleston et al., Acta Neuropathol 1996 (Brain Injuries...) : Focal trauma and human immunodeficiency virus gp120 overexpression induced M22 expression only in the hippocampus, while interleukin-6 overexpression induced it in cerebellar astrocytes
Taoufik et al., Blood 1997 : Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes : an indirect interleukin-10 mediated effect