Gene interactions and pathways from curated databases and text-mining

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MYLIP — SP1

Text-mined interactions from Literome

Ogawa et al., Biochem Biophys Res Commun 2010 : miR-29b also had an effect on SP1 expression
Niu et al., Immunology 2011 : Lipopolysaccharide induced miR-1224 negatively regulates tumour necrosis factor-a gene expression by modulating Sp1
Xu et al., J Biol Chem 2011 : miR-365 , a novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB
Zhang et al., Carcinogenesis 2011 (Pancreatic Neoplasms) : miR-132 was transcribed by RNA polymerase II, and Sp1 played a major role in miR-132 transcription
Wang et al., Am J Pathol 2011 (Carcinoma, Squamous Cell...) : Moreover, SP1 was negatively regulated by miR-375 , and knockdown of SP1 by siRNA inhibited cell malignant behaviors
Liu et al., Mol Cancer Ther 2012 (Breast Neoplasms) : Betulinic acid dependent repression of Sp1 , Sp3, Sp4, and Sp-regulated genes was due , in part, to induction of the Sp repressor ZBTB10 and downregulation of microRNA-27a (miR-27a) , which constitutively inhibits ZBTB10 expression, and we show for the first time that the effects of betulinic acid on the miR-27a : ZBTB10-Sp transcription factor axis were cannabinoid 1 (CB1) and CB2 receptor dependent, thus identifying a new cellular target for this anticancer agent
Wang et al., J Pathol 2013 (Colorectal Neoplasms...) : SP1 mediates the link between methylation of the tumour suppressor miR-149 and outcome in colorectal cancer
Guo et al., Med Oncol 2013 (Neoplasm Invasiveness...) : Moreover, we also showed that Sp1 was negatively regulated by miR-22 at the posttranscriptional level, via a specific target site within the 3'UTR by luciferase reporter assay
Mao et al., Oncol Rep 2013 : Overexpression of miR-330 by transfection of a chemically synthesized miR-330 mimic induced a reduction in expression levels of the Sp1 protein, accompanied by significant suppression of cellular migration and invasion capability