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CD4 — MSC
Text-mined interactions from Literome
Bunt et al., J Immunol 2006
(Inflammation...) :
These
myeloid suppressor cells (MSC) are present in many patients with cancer and
inhibit the activation of
CD4+ and CD8+ T lymphocytes
Zhao et al., Eur J Cancer 2012
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
CML-MSC-DCs derived TGF-ß1 was largely
responsible for the increase in
CD4+CD25+Foxp3+Tregs based on knockdown studies
Zhao et al., PloS one 2012
(Myelodysplastic Syndromes) :
At last, we find that
MDS-MSC derived TGF-ß1 is largely
responsible for the increase in
CD4+CD25+Foxp3+Tregs based on knockdown studies
Hsu et al., J Immunol 2013
(Arteriosclerosis) :
In an MLR system using porcine PBMCs,
MSC induced IL-10 ( + ) IFN-? ( + )
CD4 ( + ) cells, which confer resistance to allogeneic proliferation in an IL-10 dependent manner, resemble T(R)1-like cells ... These findings indicate that PGE ( 2 ) helps
MSC induced IL-10 ( + ) IFN-? ( + )
CD4 ( + ) T(R)1-like cells inhibit TA
Engela et al., Clin Exp Immunol 2013
:
So far it is unknown whether human
MSC induced
CD4 ( + ) CD25 ( + ) CD127 ( - ) forkhead box P3 (FoxP3) ( + ) T cells are functional and whether they originate from effector T cells or represent expanded natural regulatory T cells ( nT ( reg ) )