◀ Back to VEGFA

ARNT — VEGFA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: VEGFA → ARNT (increases, VEGFA Activity)
  Evidence: Given the multiplicity of mechanisms activating the HIF system in cancer, and the many HIF target genes involved in the angiogenic process, it is tempting to propose a simple system whereby activation of HIF in cancer promotes angiogenesis and hence tumor growth. If true, such a model would strongly support the HIF system as an anticancer target. Several studies have sought to test this model genetically in studies of experimental tumor formation by cells that are defective in particular compon...
• NCI Pathway Database HIF-1-alpha transcription factor network: HIF1A/ARNT/Cbp/p300/HDAC7 complex (HIF1A-ARNT-EP300_CREBBP-HDAC7) → VEGFA (VEGFA) (transcription, activates) Hu et al., Mol Cell Biol 2003, Kato et al., J Biol Chem 2004, Gradin et al., Mol Cell Biol 1996, Arany et al., Proc Natl Acad Sci U S A 1996
  Evidence: mutant phenotype, assay
• WikiPathways Photodynamic therapy-induced HIF-1 survival signaling: ARNT/HIF1A → SERPINE1/EDN1/NOS2/PTGS2/ANGPT1/VEGFA/TGFB3/TGFA/EPO/ANGPT2 (activation)
  
• WikiPathways Photodynamic therapy-induced HIF-1 survival signaling: ARNT/HIF1A → IGFBP1/IGFBP2/VEGFA/TGFA/TGFB3/IGFBP3 (activation)
  

Text-mined interactions from Literome

Adelman et al., Genes Dev 1999 : This defect is cell extrinsic, is accompanied by a decrease in ARNT dependent VEGF expression, and is rescued by exogenous VEGF
Nakamura et al., Cancer Res 2006 (MAP Kinase Signaling System...) : BDNF induced increases in VEGF and HIF-1alpha protein, whereas HIF-1beta levels were unaffected
Song et al., Exp Mol Med 2009 (Neovascularization, Pathologic...) : Regulation of glucose metabolism related genes and VEGF by HIF-1alpha and HIF-1beta , but not HIF-2alpha, in gastric cancer ... The results of the present study demonstrate that HIF-1alpha and HIF-1beta enhances expression of VEGF and glucose metabolism related genes in response to hypoxia in gastric cancer
Wu et al., Biochem Biophys Res Commun 2013 (Neoplasm Metastasis...) : In this study, we first confirmed the ability of LPA to induce VEGF-A expression in PC-3 cells and then validated that LPA induced VEGF-A expression was regulated by HIF-1a and ARNT through phosphatidylinositol 3-kinase activation