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HGF — VEGFA

Text-mined interactions from Literome

Wojta et al., Lab Invest 1999 : Hepatocyte growth factor increases expression of vascular endothelial growth factor and plasminogen activator inhibitor-1 in human keratinocytes and the vascular endothelial growth factor receptor flk-1 in human endothelial cells ... In this study, we show that in human keratinocytes HGF/SF but not the related cytokine macrophage stimulating protein (MSP) significantly increases expression of VEGF and plasminogen activator inhibitor-1 ( PAI-1 ) on the level of protein and mRNA ... Furthermore HGF/SF also increases the expression of VEGF in these cells, thereby initiating angiogenesis in a paracrine manner
Kuba et al., Cancer Res 2000 (Carcinoma, Lewis Lung...) : HGF and VEGF activated the Met/HGF receptor and the KDR/VEGF receptor, respectively, whereas NK4 inhibited HGF induced Met tyrosine phosphorylation but not VEGF induced KDR phosphorylation
McCourt et al., Eur J Surg Oncol 2001 (Neovascularization, Pathologic) : To examine the effects of inflammatory mediators on PMN HGF release and the effect of recombinant human HGF ( rhHGF ) on PMN adhesion receptor expression and PMN VEGF release
Dong et al., Cancer Res 2001 (Carcinoma, Squamous Cell...) : Hepatocyte growth factor/scatter factor induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma ... HGF induced a significant dose dependent increase in IL-8 and/or VEGF cytokine production in eight HNSCC lines tested, which is not observed in normal keratinocytes ... Inhibitors of MEK ( U0126 ) and PI3K ( LY294002 ) blocked p42/p44 ( erk ) and Akt, respectively, and partially blocked HGF induced production of IL-8 and VEGF , whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A
Horiguchi et al., Oncogene 2002 (Carcinoma, Hepatocellular...) : Taken together, our results suggest that HGF promotes hepatocarcinogenesis through the autocrine activation of the HGF-Met signaling pathway in association with stimulation of angiogenesis by HGF itself and/or indirectly through VEGF
Reisinger et al., J Cell Sci 2003 (Neovascularization, Pathologic) : We have shown previously that HGF/SF mediated VEGF/VPF expression by keratinocytes is primarily dependent on transcriptional activation, and we mapped the HGF/SF-responsive element to a GC-rich region between bp -88 and -65 ... Sp1-like factors bind to this element constitutively ; however the VEGF/VPF promoter is transactivated by HGF/SF in the absence of induced binding activity ... In immunoprecipitation studies, HGF/SF was found to increase the amount of serine phosphorylated Sp1, revealing a likely mechanism of HGF/SF induced VEGF/VPF expression, as phosphorylation may enhance the transcriptional activity of Sp1 ... The contribution of different signaling molecules to HGF/SF induced VEGF/VPF transcription was demonstrated by the use of chemical inhibition, of expression of kinase-deficient signaling proteins, and by the use of antisense oligonucleotides ... Herein, we provide evidence that PI 3-kinase, MEK1/2 and PKC-zeta play a significant role in HGF/SF induced VEGF/VPF promoter activation
Sengupta et al., Arterioscler Thromb Vasc Biol 2003 (MAP Kinase Signaling System...) : Hepatocyte growth factor/scatter factor ( HGF/SF ) promotes vascular endothelial growth factor ( VEGF ) expression and induces angiogenesis in multiple pathological conditions
Tomita et al., Circulation 2003 : Of importance, transfection of antisense ets-1 ODN resulted in a significant decrease in vascular endothelial growth factor ( VEGF ) and HGF expression, whereas HGF stimulated both HGF and VEGF expression
Medina et al., J Hepatol 2003 (Hepatitis C, Chronic...) : Effects of HGF on VEGF and cell adhesion molecules expression by cultured human microvascular endothelial cells were evaluated by Western blot, Northern blot or immunofluorescence ... In cultured endothelial cells, HGF transcriptionally increased VEGF expression, an effect which was blocked by an anti-VEGF receptor antibody
Zhang et al., Proc Natl Acad Sci U S A 2003 (Breast Neoplasms...) : It is known that HGF/SF induces in vitro expression of vascular endothelial growth factor ( VEGF ), a key agonist of tumor angiogenesis ; by contrast, thrombospondin 1 (TSP-1) is a negative regulator of angiogenesis
Saucier et al., Proc Natl Acad Sci U S A 2004 (Neoplasms...) : The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis
Nakamura et al., J Am Soc Nephrol 2005 (Peritonitis) : PLP and HGF prevented peritoneal thickening ; accumulation of AGE ; expression of TGF-beta1, vascular endothelial growth factor , and type 1 collagen ; and neoangiogenesis in rat peritoneum induced by PD
Naim et al., Int J Mol Med 2005 (Cholesteatoma) : Hepatocyte growth factor/scatter factor induces VEGF in human external auditory canal cholesteatoma cell culture
Min et al., Circ Res 2005 : Hepatocyte growth factor suppresses vascular endothelial growth factor induced expression of endothelial ICAM-1 and VCAM-1 by inhibiting the nuclear factor-kappaB pathway
Yokoyama et al., Oral Microbiol Immunol 2005 : Stimulation of HGF with VEGF resulted in production of IL-6 and IL-8 in a dose dependent manner
Worden et al., Cancer Res 2005 (Carcinoma, Squamous Cell...) : HGF induced expression of Egr-1, PDGFA, and VEGF was suppressed by pharmacologic and siRNA inhibitors of mitogen activated protein kinase kinase 1/2 ( MEK1/2 ) and protein kinase C ( PKC ) pathways ... We conclude that the HGF induced activation of transcription factor Egr-1 by MEK1/2- and PKC dependent mechanisms differentially contributes to expression of PDGF and VEGF , which are important angiogenesis factors and targets for HNSCC therapy
Oe et al., Hepatogastroenterology 2005 (Liver Cirrhosis, Experimental) : Hepatocyte growth factor as well as vascular endothelial growth factor gene induction effectively promotes liver regeneration after hepatectomy in Solt-Farber rats
Koga et al., Cell cycle (Georgetown, Tex.) 2007 (Breast Neoplasms...) : Notably, brief GA pretreatment inhibited in vitro invasion and VEGF secretion induced by HGF as effectively as did continuous treatment
Zhang et al., Chin Med J (Engl) 2007 (Colorectal Neoplasms...) : Inducing effects of hepatocyte growth factor on the expression of vascular endothelial growth factor in human colorectal carcinoma cells through MEK and PI3K signaling pathways ... In this study, we investigated whether hepatocyte growth factor can regulate the expression of vascular endothelial growth factor in colorectal carcinoma cells ... Specific inhibitors on MEK and PI3K inhibited the hepatocyte growth factor induced expression of vascular endothelial growth factor in colorectal carcinoma cells ... This present study indicates that hepatocyte growth factor upregulates the expression of vascular endothelial growth factor in colorectal carcinoma cells via the MEK/ERK and PI3K/AKT signaling pathways
Abid et al., Arterioscler Thromb Vasc Biol 2008 : HGF mediated inhibition of VEGF-inducible VCAM-1 expression and monocyte adhesion was reversed by overexpression of constitutively active phosphorylation-resistant triple mutant ( TM ) -FKHR
Yamamoto et al., J Surg Res 2010 : Portal VEGF was significantly higher than systemic VEGF, and expressions of VEGF, HIF-1alpha, HGF , and HGFA mRNA in the liver, spleen and intestine were also up-regulated during liver regeneration
Zisa et al., Am J Physiol Regul Integr Comp Physiol 2009 (Disease Models, Animal...) : VEGF also induced production of HGF , IGF2, and VEGF by skeletal muscle
Xu et al., J Biol Chem 2011 : Expression of RPTP-ß in human primary keratinocytes reduces HGF induction of VEGF expression, proliferation, and motility
Takeuchi et al., Am J Pathol 2012 (Lung Neoplasms...) : HGF stimulated VEGF production by activation of the Met/Gab1 signaling pathway in EGFR mutant lung cancer cell lines, and E7050 showed an inhibitory effect
Lin et al., PloS one 2012 : Hepatocyte growth factor increases vascular endothelial growth factor-A production in human synovial fibroblasts through c-Met receptor pathway ... Pretreatment with PI3K inhibitor ( Ly294002 ), Akt inhibitor, or mTORC1 inhibitor ( rapamycin ) blocked the HGF induced VEGF-A production ... Taken together, our results provide evidence that HGF enhances VEGF-A expression in OASFs by an HIF-1a dependent mechanism involving the activation of c-Met/PI3K/Akt and mTORC1 pathways
Kubota et al., Oncol Rep 2013 : It is known that HGF induces in vitro expression of vascular endothelial growth factor ( VEGF ), a key agonist of tumor angiogenesis
Van Belle et al., Circulation 1998 (Ischemia) : The synergistic effects demonstrated when SF/HGF and VEGF are administered together in vitro may be reproduced in vivo by SF/HGF induced upregulation of VEGF in vascular SMCs
Kumar et al., Int J Oncol 1998 : HGF, bFGF, and VEGF/VPF induced chemotactic migration of the endothelial cells, but only HGF ( scatter factor ) enhanced nondirectional motility
Clifford et al., Br J Cancer 1998 : Our evidence would suggest that the changes in PTEC VEGF expression induced by HGF/SF are mediated by a VHL independent pathway
Moriyama et al., Biochem Biophys Res Commun 1998 (Glioma) : We investigated the effect of HGF/SF on vascular endothelial growth factor ( VEGF ) expression of c-Met/HGF receptor positive human glioma cell lines ... Since malignant gliomas frequently co-express HGF/SF and its receptor, these results suggest that HGF/SF could act as an indirect angiogenic factor through autocrine induction of VEGF expression and secretion in malignant gliomas
Gille et al., J Invest Dermatol 1998 : Hepatocyte growth factor/scatter factor ( HGF/SF ) induces vascular permeability factor ( VPF/VEGF ) expression by cultured keratinocytes ... Thus, HGF/SF induced VPF/VEGF mRNA expression appears to be largely dependent on enhanced gene transcription