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BLNK — GRB2

Pathways - manually collected, often from reviews:

• BioCarta bcr signaling pathway: B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• KEGG B cell receptor signaling pathway: BLNK → GRB2 (protein-protein, binding/association)
• Reactome Reaction: GRB2 → BLNK (direct_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: GRB2 — BLNK (physical association, affinity chromatography technology) Oellerich et al., EMBO J 2011
• IRef Biogrid Interaction: GRB2 — BLNK (physical association, affinity chromatography technology) Fusaki et al., Eur J Immunol 2000
• IRef Biogrid Interaction: GRB2 — BLNK (physical association, affinity chromatography technology) Fu et al., Immunity 1998
• IRef Biogrid Interaction: GRB2 — BLNK (direct interaction, pull down) Engels et al., Eur J Immunol 2001
• IRef Biogrid Interaction: GRB2 — BLNK (direct interaction, pull down) Wienands et al., J Exp Med 1998
• IRef Hprd Interaction: BLNK — GRB2 (in vitro) Fu et al., Immunity 1998, Wienands et al., J Exp Med 1998
• IRef Hprd Interaction: BLNK — GRB2 (in vivo) Fu et al., Immunity 1998, Wienands et al., J Exp Med 1998
• IRef Hprd Interaction: Complex of 50 proteins (in vivo) Watanabe et al., Biochem Biophys Res Commun 2000
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Janssen et al., Nat Immunol 2003*
• IRef Intact Interaction: GRB2 — BLNK (physical association, pull down) Su et al., Eur J Immunol 1999
• IRef Intact Interaction: GRB2 — BLNK (direct interaction, isothermal titration calorimetry) Grabbe et al., Blood 2006*
• IRef Intact Interaction: GRB2 — BLNK (physical association, pull down) Grabbe et al., Blood 2006*
• IRef Intact Interaction: Complex of MAP2K4-BLNK-CD2AP-DOK3-GRB2-PLCG2 (association, anti bait coimmunoprecipitation) Oellerich et al., EMBO J 2011
• IRef Ophid Interaction: GRB2 — BLNK (aggregation, interologs mapping) Brown et al., Bioinformatics 2005