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TFDP1 — TP53

Pathways - manually collected, often from reviews:

• FastForward regulation: TFDP1 → TP53 (transcriptional regulation, increase) Hiebert et al., Mol Cell Biol 1995*
  Evidence: REG
• NCI Pathway Database Direct p53 effectors: E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) → p53 (tetramer) complex (TP53) (transcription, activates)
  Bist et al., Biochemistry 2000
  Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TFDP1 — TP53 (physical association, affinity chromatography technology) Sørensen et al., Mol Cell Biol 1996*
• IRef Biogrid Interaction: TFDP1 — TP53 (direct interaction, pull down) Sørensen et al., Mol Cell Biol 1996*
• IRef Hprd Interaction: TP53 — TFDP1 (in vivo) Sørensen et al., Mol Cell Biol 1996*
• IRef Hprd Interaction: TP53 — TFDP1 (in vitro) Sørensen et al., Mol Cell Biol 1996*
• IRef Ophid Interaction: TFDP1 — TP53 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: TFDP1 — TP53 (aggregation, confirmational text mining) Sørensen et al., Mol Cell Biol 1996*

Text-mined interactions from Literome

Hiebert et al., Mol Cell Biol 1995 : E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis
Gopalkrishnan et al., J Biol Chem 1998 : In this report, we show that expression of the cell cycle regulatory transcription factor DP1 is strongly inhibited by p53 , at the level of transcription and probably through the basal TATA-less promoter