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PEA15 — RPS6KA3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
PEA15
—
RPS6KA3
Vaidyanathan et al., J Biol Chem 2003*
-
IRef Bind_translation Interaction:
PEA15
—
RPS6KA3
(affinity chromatography technology)
Vaidyanathan et al., J Biol Chem 2003*
-
IRef Bind_translation Interaction:
PEA15
—
RPS6KA3
(coimmunoprecipitation)
Vaidyanathan et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
PEA15
—
RPS6KA3
(physical association, affinity chromatography technology)
Vaidyanathan et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
PEA15
—
RPS6KA3
(direct interaction, pull down)
Vaidyanathan et al., J Biol Chem 2003*
-
IRef Hprd Interaction:
PEA15
—
RPS6KA3
(in vitro)
Vaidyanathan et al., J Biol Chem 2003*
-
IRef Hprd Interaction:
PEA15
—
RPS6KA3
(in vivo)
Vaidyanathan et al., J Biol Chem 2003*
-
IRef Ophid Interaction:
PEA15
—
RPS6KA3
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Vaidyanathan et al., J Biol Chem 2003
:
RSK2 activity is
regulated by its interaction with
PEA-15 ... First,
PEA-15 blocks nuclear accumulation of
RSK2 after epidermal growth factor stimulation ... Second,
PEA-15 inhibits
RSK2 kinase activity by 50 % ... This may indicate that cytoplasmic retention of
RSK2 is also
required for
PEA-15 to impair kinase activity ... Hence the
effects of
PEA-15 on
RSK2 represent a novel mechanism for the regulation of RSK2 mediated signaling
Vaidyanathan et al., Proc Natl Acad Sci U S A 2007
(MAP Kinase Signaling System) :
We demonstrate that
PEA-15 ( phosphoprotein enriched in astrocytes, 15 kDa )
targets ERK to
RSK2 and thereby enhances RSK2 activation ...
PEA-15 independently bound ERK and RSK2 and
increased ERK association with
RSK2 in a concentration dependent manner ...
PEA-15 increased
RSK2 activity and CREB mediated transcription, and this process was regulated by phosphorylation of PEA-15
Gawecka et al., Int J Cancer 2012
(Chromosome Aberrations...) :
Phosphoprotein enriched in astrocytes 15 ( PEA15 ) binds ERK and
RSK2 and high
PEA15 levels can
impair ERK- and RSK2 dependent transcription