◀ Back to MAPK3
CSF2 — MAPK3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Hu et al., Cell Growth Differ 2000
(Leukemia, Myeloid...) :
In contrast, treatment of TF-1a cells with
granulocyte/macrophage-colony stimulating factor induced only transient
activation of MEK and p44/42
MAPK ( 10-20 min ) and an increase ( approximately 50 % ) in cell proliferation, without any change in cellular differentiation
Lehman et al., Am J Physiol Cell Physiol 2001
:
Interestingly, peripheral blood neutrophils expressed the highest ( 16-fold )
MAPK activation level in
response to
GM-CSF
Zubkov et al., Stroke 2001
(Disease Models, Animal...) :
( 6 ) Hemolysate, oxyhemoglobin, and bloody
CSF significantly
increased MAPK activity in the rabbit basilar artery ... ( 7 ) U0126 abolished the
effect of hemolysate, oxyhemoglobin, or bloody
CSF on
MAPK activation
Suzuki et al., J Immunol 2001
(Inflammation) :
In addition,
GM-CSF- and TNF induced superoxide release and adherence were
inhibited by PD98059 MAPK/ERK kinase inhibitor ) as well as SB203580 ( p38
MAPK inhibitor ), suggesting possible involvement of ERK and p38 MAPK in superoxide release and adherence induced by these cytokines
Hallsworth et al., Am J Respir Crit Care Med 2001
(Asthma...) :
In the present study, we examined a
requirement for
mitogen activated protein ( MAP ) kinase activation for interleukin (IL)-1beta stimulated
GM-CSF , RANTES, and eotaxin release
Irusen et al., J Allergy Clin Immunol 2002
(Asthma) :
Activation of p38
MAPK by IL-2 and IL-4, as shown by means of phosphorylation of activated transcription factor 2, resulted in GR phosphorylation and
reduced dexamethasone repression of LPS stimulated
GM-CSF release
Cárcamo et al., Blood 2002
:
Vitamin C suppressed
GM-CSF dependent phosphorylation of the signal transducer and activator of transcription 5 ( Stat-5 ) and
mitogen activated protein ( MAP ) kinase ( Erk1 and Erk2 ) in a dose dependent manner as was phosphorylation of MAP kinase induced by both interleukin 3 (IL-3) and GM-CSF in HL-60 cells
Bozinovski et al., J Biol Chem 2002
(MAP Kinase Signaling System) :
LPS markedly activated Akt and
Erk1/2 , but not p38, in a
GM-CSF dependent manner in direct temporal association with NFkappaB and AP-1 activation
Wong et al., Am J Respir Cell Mol Biol 2003
:
IL-3, IL-5, and
GM-CSF could
enhance p38
MAPK and NF-kappaB activity and induce ICAM-1, CD11b, and CD18 expressions on eosinophils
Kutsuna et al., Am J Physiol Cell Physiol 2004
:
These findings suggest that TNF,
GM-CSF , and G-CSF
induce actin depolymerization and morphological changes through activation of ERK and/or p38
MAPK and that cytokine induced actin reorganization may be partly responsible for the inhibitory effect of these cytokines on neutrophil chemotaxis
Raines et al., Blood 1992
(Leukemia, Promyelocytic, Acute) :
Granulocyte-macrophage
colony stimulating factor activates
microtubule associated protein 2 kinase in neutrophils via a tyrosine kinase dependent pathway
Pei et al., Acta Pharmacol Sin 2003
(MAP Kinase Signaling System) :
And mitogen activated protein kinase (
MAPK ) inhibitor, PD 98059 ( 10 micromol/L ), completely
blocked IGF-1,
GM-CSF , and EGF induced expression of Cbfa1 promoter activity ( P < 0.01 )
Tortorella et al., Mech Ageing Dev 2004
:
No changes in
GM-CSF induced p38
MAPK phosphorylation were observed
Baumann et al., Leuk Res 2005
:
Although both
GM-CSF and G-CSF
activate p42/44
MAPK in neutrophil progenitors, the ability of G-CSF to cause MAPK activation is lost in mature neutrophils, while GM-CSF exposure still causes activation
Senokuchi et al., J Biol Chem 2005
:
Statins did not inhibit Ox-LDL induced
GM-CSF production, but
inhibited GM-CSF induced p38
MAPK activation ...
GM-CSF induced p38
MAPK activation and macrophage proliferation was partially inhibited by overexpression of dominant negative Ras and completely by that of RhoA ...
GM-CSF induced p38
MAPK phosphorylation was also inhibited by farnesyl transferase inhibitor or geranylgeranyl transferase inhibitor, and farnesyl pyrophosphate and geranylgeranyl pyrophosphate prevented the suppression of GM-CSF induced p38 MAPK phosphorylation by statins ... In conclusion, statins inhibited
GM-CSF induced Ras- or RhoA-p38
MAPK signal cascades, thereby suppressing Ox-LDL induced macrophage proliferation
Ip et al., Immunopharmacol Immunotoxicol 2005
:
IL-3, IL-5, and
GM-CSF could
augment the phosphorylation of p38
MAPK and nucleus translocation of NF-kappaB in eosinophils
Smith et al., Br J Pharmacol 2006
(Pneumonia) :
p38 MAPK may regulate cytokine production, therefore, the
effect of two p38
MAPK inhibitors, SB239063 and SD-282, on the release of TNF-alpha,
GM-CSF and IL-8 from human macrophages was investigated
Chen et al., Zhonghua Nan Ke Xue 2006
(Neoplasms, Hormone-Dependent...) :
[ Role of
MAPK signal transduction pathway phosphorylation
induced by
granulocyte-macrophage-colony stimulating factor in the proliferation of hormone independent prostate cancer ]
ten Hove et al., Mol Immunol 2007
:
Differential regulation of TNFalpha and
GM-CSF induced activation of P38
MAPK in neutrophils and eosinophils
Zaheer et al., J Neurochem 2007
(Encephalitis...) :
Inhibition of p38
MAPK or NF-kappaB by specific inhibitors
prevented GM-CSF production
Uemura et al., Int J Lab Hematol 2009
(Leukemia, Neutrophilic, Chronic) :
We also showed that stat3 and
mitogen activated protein kinase activation by G-CSF or
GM-CSF in the patient 's neutrophils were significantly lower than those in healthy donor neutrophils
Ha et al., FEBS J 2008
(Arthritis, Rheumatoid) :
These results imply that
GM-CSF signaling
activates mitogen activated protein kinase , followed by the upregulation of MLN51 and FLICE-inhibitory protein, resulting in fibroblast-like synoviocyte hyperplasia in rheumatoid arthritis
Liu et al., Invest Ophthalmol Vis Sci 2008
:
Poly ( I:C ) -induced expression of IL-6, IL-8,
G-CSF , MIP-1beta, exotaxin, RANTES, and ICAM-1 was
inhibited differentially by the
MAPK inhibitors PD98059 and SB203580 and by JNK inhibitor II
Shen et al., Nat Immunol 2009
:
Granulocyte-macrophage
colony stimulating factor induced activation of the kinase
Erk1/2 , which phosphorylated Thr167 of Bax ; this facilitated new interaction of Bax with the prolyl isomerase Pin1
Zhou et al., PloS one 2009
(MAP Kinase Signaling System) :
This identifies a novel role for
MEK/MAPK mediated
cytostatic factor (CSF) activity during meiosis in membrane protein trafficking in mouse oocytes, and shows for the first time that selective retrieval of membrane proteins is a feature of meiosis in mammalian oocytes
Ishii et al., J Biol Chem 2009
:
AICAR suppressed
GM-CSF induced macrophage proliferation without suppressing p38
MAPK/Akt signaling
Knobloch et al., Thorax 2009
:
ET-1- and TNFalpha induced
GM-CSF expression were both
reduced by bosentan as well as by specific inhibition of either ET ( A ) R, ET ( B ) R, p38 (
MAPK ) or ERK-1/-2
Liontos et al., J Immunol 2011
:
In bone marrow derived DC ( BM-DC ) lacking SLAP and the closely related SLAP2, downregulation of GM-CSFRß is impaired, leading to enhanced phosphorylation of Jak2 and prolonged activation of Akt and
Erk1/2 in
response to
GM-CSF stimulation
Dohgu et al., Journal of neuroinflammation 2011
:
These results show that p44/42 and p38
MAPK signaling pathways
mediate the LPS enhanced release of IL-6 and
GM-CSF
Chatterjee et al., J Biol Chem 2013
(Cholera...) :
These vesicles
induced expression of proinflammatory cytokines such as IL-8 and
GM-CSF and chemokines such as CCL2, CCL20, and thymic stromal lymphopoietin in epithelial cells through activation of
MAPK and NF-?B pathways in NOD1 dependent manner
Reece et al., Immunology 2013
:
We show for the first time that LPS stimulation of CB progenitor cells results in autocrine activation of p38
MAPK dependent
GM-CSF secretion facilitating Eo/B differentiation ex vivo
Büscher et al., Mol Cell Biol 1995
:
Expression of a dominant negative ras mutant reduced, but did not abolish,
CSF-1 mediated stimulation of MEK and
MAPK
Csar et al., Biochem J 1997
(Leukemia, Myeloid) :
cAMP suppresses p21ras and Raf-1 responses but not the
Erk-1 response to
granulocyte-colony stimulating factor : possible Raf-1 independent activation of Erk-1
Jiao et al., Exp Hematol 1997
:
Despite the heightened growth responses of the motheaten macrophages to GM-CSF, there were no marked differences between motheaten macrophages and normal controls in
GM-CSF induced phosphorylation of GM-CSFR beta, Jak2, STAT5 and
MAPK , indicating that these molecules are not major HCP substrates in GM-CSF signaling
Hiraguri et al., J Allergy Clin Immunol 1997
:
Granulocyte-macrophage
colony stimulating factor and IL-5
activate mitogen activated protein kinase through Jak2 kinase and phosphatidylinositol 3-kinase in human eosinophils
Villunger et al., Br J Haematol 1998
(Multiple Myeloma...) :
The expressed cytokine receptor alpha-subunit was able to constitute a functional signalling complex with the ubiquitously expressed GM-CSFRbeta subunit, as demonstrated by the fact that
GM-CSF induced the p21-ras/mitogen activated protein kinase (
MAPK ) signalling cascade in malignant plasma cell lines
McLeish et al., J Leukoc Biol 1998
:
The phosphatidylinositol 3-kinase inhibitor, wortmannin, attenuated
stimulation of ERKs and p38
MAPK by
GM-CSF , but not TNF-alpha ... Our data suggest that TNF-alpha and
GM-CSF activate ERKs and p38
MAPK by different signal transduction pathways
Suzuki et al., Blood 1999
:
MEK inhibitor ( PD98059 ) reduced tyrosine phosphorylation of ERK, but not p38
MAPK ,
induced by G-CSF,
GM-CSF , or TNF ...
GM-CSF- or TNF induced superoxide ( O2- ) release was
inhibited by p38
MAPK inhibitor ( SB203580 ) in a dose dependent manner, suggesting the possible involvement of p38 MAPK in GM-CSF- or TNF induced O2- release
Aoshiba et al., J Immunol 1999
:
Granulocyte-macrophage
CSF and anti-Fas Ab, which altered the rate of apoptosis, did not
affect phosphorylation and activation of
p38-MAPK