Gene interactions and pathways from curated databases and text-mining

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CSF2 — MAPK3

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Hu et al., Cell Growth Differ 2000 (Leukemia, Myeloid...) : In contrast, treatment of TF-1a cells with granulocyte/macrophage-colony stimulating factor induced only transient activation of MEK and p44/42 MAPK ( 10-20 min ) and an increase ( approximately 50 % ) in cell proliferation, without any change in cellular differentiation
Lehman et al., Am J Physiol Cell Physiol 2001 : Interestingly, peripheral blood neutrophils expressed the highest ( 16-fold ) MAPK activation level in response to GM-CSF
Zubkov et al., Stroke 2001 (Disease Models, Animal...) : ( 6 ) Hemolysate, oxyhemoglobin, and bloody CSF significantly increased MAPK activity in the rabbit basilar artery ... ( 7 ) U0126 abolished the effect of hemolysate, oxyhemoglobin, or bloody CSF on MAPK activation
Suzuki et al., J Immunol 2001 (Inflammation) : In addition, GM-CSF- and TNF induced superoxide release and adherence were inhibited by PD98059 MAPK/ERK kinase inhibitor ) as well as SB203580 ( p38 MAPK inhibitor ), suggesting possible involvement of ERK and p38 MAPK in superoxide release and adherence induced by these cytokines
Hallsworth et al., Am J Respir Crit Care Med 2001 (Asthma...) : In the present study, we examined a requirement for mitogen activated protein ( MAP ) kinase activation for interleukin (IL)-1beta stimulated GM-CSF , RANTES, and eotaxin release
Irusen et al., J Allergy Clin Immunol 2002 (Asthma) : Activation of p38 MAPK by IL-2 and IL-4, as shown by means of phosphorylation of activated transcription factor 2, resulted in GR phosphorylation and reduced dexamethasone repression of LPS stimulated GM-CSF release
Cárcamo et al., Blood 2002 : Vitamin C suppressed GM-CSF dependent phosphorylation of the signal transducer and activator of transcription 5 ( Stat-5 ) and mitogen activated protein ( MAP ) kinase ( Erk1 and Erk2 ) in a dose dependent manner as was phosphorylation of MAP kinase induced by both interleukin 3 (IL-3) and GM-CSF in HL-60 cells
Bozinovski et al., J Biol Chem 2002 (MAP Kinase Signaling System) : LPS markedly activated Akt and Erk1/2 , but not p38, in a GM-CSF dependent manner in direct temporal association with NFkappaB and AP-1 activation
Wong et al., Am J Respir Cell Mol Biol 2003 : IL-3, IL-5, and GM-CSF could enhance p38 MAPK and NF-kappaB activity and induce ICAM-1, CD11b, and CD18 expressions on eosinophils
Kutsuna et al., Am J Physiol Cell Physiol 2004 : These findings suggest that TNF, GM-CSF , and G-CSF induce actin depolymerization and morphological changes through activation of ERK and/or p38 MAPK and that cytokine induced actin reorganization may be partly responsible for the inhibitory effect of these cytokines on neutrophil chemotaxis
Raines et al., Blood 1992 (Leukemia, Promyelocytic, Acute) : Granulocyte-macrophage colony stimulating factor activates microtubule associated protein 2 kinase in neutrophils via a tyrosine kinase dependent pathway
Pei et al., Acta Pharmacol Sin 2003 (MAP Kinase Signaling System) : And mitogen activated protein kinase ( MAPK ) inhibitor, PD 98059 ( 10 micromol/L ), completely blocked IGF-1, GM-CSF , and EGF induced expression of Cbfa1 promoter activity ( P < 0.01 )
Tortorella et al., Mech Ageing Dev 2004 : No changes in GM-CSF induced p38 MAPK phosphorylation were observed
Baumann et al., Leuk Res 2005 : Although both GM-CSF and G-CSF activate p42/44 MAPK in neutrophil progenitors, the ability of G-CSF to cause MAPK activation is lost in mature neutrophils, while GM-CSF exposure still causes activation
Senokuchi et al., J Biol Chem 2005 : Statins did not inhibit Ox-LDL induced GM-CSF production, but inhibited GM-CSF induced p38 MAPK activation ... GM-CSF induced p38 MAPK activation and macrophage proliferation was partially inhibited by overexpression of dominant negative Ras and completely by that of RhoA ... GM-CSF induced p38 MAPK phosphorylation was also inhibited by farnesyl transferase inhibitor or geranylgeranyl transferase inhibitor, and farnesyl pyrophosphate and geranylgeranyl pyrophosphate prevented the suppression of GM-CSF induced p38 MAPK phosphorylation by statins ... In conclusion, statins inhibited GM-CSF induced Ras- or RhoA-p38 MAPK signal cascades, thereby suppressing Ox-LDL induced macrophage proliferation
Ip et al., Immunopharmacol Immunotoxicol 2005 : IL-3, IL-5, and GM-CSF could augment the phosphorylation of p38 MAPK and nucleus translocation of NF-kappaB in eosinophils
Smith et al., Br J Pharmacol 2006 (Pneumonia) : p38 MAPK may regulate cytokine production, therefore, the effect of two p38 MAPK inhibitors, SB239063 and SD-282, on the release of TNF-alpha, GM-CSF and IL-8 from human macrophages was investigated
Chen et al., Zhonghua Nan Ke Xue 2006 (Neoplasms, Hormone-Dependent...) : [ Role of MAPK signal transduction pathway phosphorylation induced by granulocyte-macrophage-colony stimulating factor in the proliferation of hormone independent prostate cancer ]
ten Hove et al., Mol Immunol 2007 : Differential regulation of TNFalpha and GM-CSF induced activation of P38 MAPK in neutrophils and eosinophils
Zaheer et al., J Neurochem 2007 (Encephalitis...) : Inhibition of p38 MAPK or NF-kappaB by specific inhibitors prevented GM-CSF production
Uemura et al., Int J Lab Hematol 2009 (Leukemia, Neutrophilic, Chronic) : We also showed that stat3 and mitogen activated protein kinase activation by G-CSF or GM-CSF in the patient 's neutrophils were significantly lower than those in healthy donor neutrophils
Ha et al., FEBS J 2008 (Arthritis, Rheumatoid) : These results imply that GM-CSF signaling activates mitogen activated protein kinase , followed by the upregulation of MLN51 and FLICE-inhibitory protein, resulting in fibroblast-like synoviocyte hyperplasia in rheumatoid arthritis
Liu et al., Invest Ophthalmol Vis Sci 2008 : Poly ( I:C ) -induced expression of IL-6, IL-8, G-CSF , MIP-1beta, exotaxin, RANTES, and ICAM-1 was inhibited differentially by the MAPK inhibitors PD98059 and SB203580 and by JNK inhibitor II
Shen et al., Nat Immunol 2009 : Granulocyte-macrophage colony stimulating factor induced activation of the kinase Erk1/2 , which phosphorylated Thr167 of Bax ; this facilitated new interaction of Bax with the prolyl isomerase Pin1
Zhou et al., PloS one 2009 (MAP Kinase Signaling System) : This identifies a novel role for MEK/MAPK mediated cytostatic factor (CSF) activity during meiosis in membrane protein trafficking in mouse oocytes, and shows for the first time that selective retrieval of membrane proteins is a feature of meiosis in mammalian oocytes
Ishii et al., J Biol Chem 2009 : AICAR suppressed GM-CSF induced macrophage proliferation without suppressing p38 MAPK/Akt signaling
Knobloch et al., Thorax 2009 : ET-1- and TNFalpha induced GM-CSF expression were both reduced by bosentan as well as by specific inhibition of either ET ( A ) R, ET ( B ) R, p38 ( MAPK ) or ERK-1/-2
Liontos et al., J Immunol 2011 : In bone marrow derived DC ( BM-DC ) lacking SLAP and the closely related SLAP2, downregulation of GM-CSFRß is impaired, leading to enhanced phosphorylation of Jak2 and prolonged activation of Akt and Erk1/2 in response to GM-CSF stimulation
Dohgu et al., Journal of neuroinflammation 2011 : These results show that p44/42 and p38 MAPK signaling pathways mediate the LPS enhanced release of IL-6 and GM-CSF
Chatterjee et al., J Biol Chem 2013 (Cholera...) : These vesicles induced expression of proinflammatory cytokines such as IL-8 and GM-CSF and chemokines such as CCL2, CCL20, and thymic stromal lymphopoietin in epithelial cells through activation of MAPK and NF-?B pathways in NOD1 dependent manner
Reece et al., Immunology 2013 : We show for the first time that LPS stimulation of CB progenitor cells results in autocrine activation of p38 MAPK dependent GM-CSF secretion facilitating Eo/B differentiation ex vivo
Büscher et al., Mol Cell Biol 1995 : Expression of a dominant negative ras mutant reduced, but did not abolish, CSF-1 mediated stimulation of MEK and MAPK
Csar et al., Biochem J 1997 (Leukemia, Myeloid) : cAMP suppresses p21ras and Raf-1 responses but not the Erk-1 response to granulocyte-colony stimulating factor : possible Raf-1 independent activation of Erk-1
Jiao et al., Exp Hematol 1997 : Despite the heightened growth responses of the motheaten macrophages to GM-CSF, there were no marked differences between motheaten macrophages and normal controls in GM-CSF induced phosphorylation of GM-CSFR beta, Jak2, STAT5 and MAPK , indicating that these molecules are not major HCP substrates in GM-CSF signaling
Hiraguri et al., J Allergy Clin Immunol 1997 : Granulocyte-macrophage colony stimulating factor and IL-5 activate mitogen activated protein kinase through Jak2 kinase and phosphatidylinositol 3-kinase in human eosinophils
Villunger et al., Br J Haematol 1998 (Multiple Myeloma...) : The expressed cytokine receptor alpha-subunit was able to constitute a functional signalling complex with the ubiquitously expressed GM-CSFRbeta subunit, as demonstrated by the fact that GM-CSF induced the p21-ras/mitogen activated protein kinase ( MAPK ) signalling cascade in malignant plasma cell lines
McLeish et al., J Leukoc Biol 1998 : The phosphatidylinositol 3-kinase inhibitor, wortmannin, attenuated stimulation of ERKs and p38 MAPK by GM-CSF , but not TNF-alpha ... Our data suggest that TNF-alpha and GM-CSF activate ERKs and p38 MAPK by different signal transduction pathways
Suzuki et al., Blood 1999 : MEK inhibitor ( PD98059 ) reduced tyrosine phosphorylation of ERK, but not p38 MAPK , induced by G-CSF, GM-CSF , or TNF ... GM-CSF- or TNF induced superoxide ( O2- ) release was inhibited by p38 MAPK inhibitor ( SB203580 ) in a dose dependent manner, suggesting the possible involvement of p38 MAPK in GM-CSF- or TNF induced O2- release
Aoshiba et al., J Immunol 1999 : Granulocyte-macrophage CSF and anti-Fas Ab, which altered the rate of apoptosis, did not affect phosphorylation and activation of p38-MAPK