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ARSK — JUN
Text-mined interactions from Literome
Geleziunas et al., Nature 2001
:
The interaction of Nef with
ASK1 inhibits both Fas- and TNFalpha mediated apoptosis, as well as the activation of the downstream
c-Jun amino-terminal kinase
Chang et al., Exp Cell Res 2002
:
This suggests that IL-8 induction by LTbetaR is via TRAFs elicited signaling pathways, including NIK/IKK dependent NF-kappaB activation and
ASK/MKK/JNK dependent
AP-1 activation
Hwang et al., FEBS Lett 2002
:
Cotransfection with ALG-2 resulted in the nuclear
presence of
ASK1 and inhibited the activation of
c-Jun N-terminal kinase (JNK) by ASK1 in BOSC23 cells
Yamagishi et al., J Biochem 2003
:
On the other hand, the expression of
ASK1-DeltaN , a constitutively active form of ASK1,
activated p38 and
c-Jun , but not JNK, another possible downstream target of ASK1
Kumasawa et al., Eur J Pharmacol 2005
:
The results showed that LTD ( 4 ) induced AP-1 activation determined by
AP-1 dependent luciferase gene activity and
ASK1 phosphorylation ... These results indicate that LTD ( 4 ) is capable of inducing AP-1 activation and
ASK1 regulates
AP-1 activation in LTD ( 4 ) -stimulated airway smooth muscle cells
Li et al., Crit Care Med 2005
:
ASK1 inhibition with thioredoxin
attenuated high tidal volume ventilation induced MIP-2 messenger RNA expression, MIP-2 protein production, neutrophil migration into the lung, airway epithelial cell apoptosis, activation of JNK, and
AP-1 DNA binding
Hikoso et al., J Am Coll Cardiol 2007
(Disease Models, Animal...) :
Inhibition of
ASK1 reduced the number of apoptotic cells and selectively
attenuated c-Jun NH2-terminal kinase activation
Yu et al., J Immunol 2009
:
Furthermore, thrombin mediated
AP-1 activation was
inhibited by
ASK1DN , JNK1/2DN, and SP600125
Gu et al., Oncogene 2009
:
PIM1 phosphorylation of
ASK1 on Ser83
inhibited ASK1 mediated
c-Jun N-terminal kinase phosphorylation as well as p38 kinase phosphorylation
Seong et al., J Biol Chem 2010
:
PDK1 functionally suppresses
ASK1 mediated
AP-1 transactivation and H ( 2 ) O ( 2 ) -mediated apoptosis in a kinase dependent manner
Liu et al., PloS one 2012
(MAP Kinase Signaling System) :
CTGF mediated increase of NF-?B and
AP-1 luciferase activity was
inhibited by SB203580 and SP600125 or
ASK1 shRNA or p38 and JNK mutant