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Lin et al., Cell Death Differ 2006
:
Here we report that calpain mediated Cdk5/p25 activation accompanies non-neuronal as well as neuronal cell death, suggesting that the p35/calpain/p25/Cdk5 activation sequence is a general feature of cell death
Ye et al., J Biomed Biotechnol 2009
(Necrosis) :
The kinase is typically activated by p25 , derived from p35 by calpain mediated cleavage, but inhibition of calpain does not affect cell death or the activation of Cdk5