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MMP9 — PRKCA

Text-mined interactions from Literome

Xie et al., J Biol Chem 2004 : These observations suggest that 1 ) activation of ERK1/2 and JNKs plays a critical role in the regulation of MMP-9, not MMP-2, expression and activity ; 2 ) PKC-alpha/beta1 act upstream of JNKs, not ERK1/2 ; 3 ) PKC-zeta and -theta, not PKC-epsilon, act upstream of JNKs, ERK1/2, and NF-kappaB ; and 4 ) activation of NF-kappaB stimulates expression and activity of MMP-2 and -9
Chakrabarti et al., J Leukoc Biol 2006 (MAP Kinase Signaling System) : Inhibitors against specific PKC isoforms suggested a role for PKC alpha and PKC delta in maximal MMP-9 release
Shin et al., Exp Mol Med 2007 : PMA activated NF-kappaB by phosphorylating IkappaB in these cells and this was also inhibited by GF109203X and Go6976, suggesting that PKCa acts as an upstream regulator of NF-kappaB in PMA induced MMP-9 induction
Matou-Nasri et al., Int J Oncol 2009 : This suggests that endothelial tube formation involves activation of MMP9 via PKC-alpha